Radiochemistry on chip: towards dose-on-demand synthesis of PET radiopharmaceuticals

被引：62

作者：

Arima, Valentina ^{[1
]}

Pascali, Giancarlo ^{[2
,3
]}

Lade, Oliver ^{[4
]}

Kretschmer, Hans R. ^{[4
]}

Bernsdorf, Ingo ^{[4
]}

Hammond, Victoria ^{[5
]}

Watts, Paul ^{[5
,6
]}

De Leonardis, Francesco ^{[5
]}

Tarn, Mark D. ^{[5
]}

Pamme, Nicole ^{[5
]}

Cvetkovic, Benjamin Z. ^{[7
]}

Dittrich, Petra S. ^{[7
]}

Vasovic, Nikola ^{[8
]}

Duane, Russell ^{[8
]}

Jaksic, Aleksandar ^{[8
]}

Zacheo, Antonella ^{[1
,9
]}

Zizzari, Alessandra ^{[1
]}

Marra, Lucia ^{[1
]}

Perrone, Elisabetta ^{[1
]}

Salvadori, Piero A. ^{[2
]}

Rinaldi, Rosaria ^{[1
,9
]}

机构：

[1] CNR, Inst Nanosci NANO, Natl Nanotechnol Lab, I-73100 Lecce, Italy

[2] CNR, Inst Clin Physiol, I-56124 Pisa, Italy

[3] Australian Nucl Sci & Technol Org, Div Life Sci, Kirrawee Dc, NSW 2232, Australia

[4] Siemens AG, D-13629 Berlin, Germany

[5] Univ Hull, Dept Chem, Kingston Upon Hull HU6 7RX, N Humberside, England

[6] Nelson Mandela Metropolitan Univ, InnoVenton NMMU Inst Chem Technol, RA-6031 Port Elizabeth, South Africa

[7] ETH, Dept Chem & Appl Biosci, CH-8093 Zurich, Switzerland

[8] Tyndall Natl Inst, Cork, Ireland

[9] Univ Salento, Dipartimento Matemat & Fis E De Giorgi, I-73100 Lecce, Italy

来源：

LAB ON A CHIP | 2013年 / 13卷 / 12期

关键词：

REACTOR; RADIOSYNTHESIS; MICROFLUIDICS; MICROREACTORS;

D O I：

10.1039/c3lc00055a

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

We have developed an integrated microfluidic platform for producing 2-[F-18]-fluoro-2-deoxy-D-glucose(F-18-FDG) in continuous flow from a single bolus of radioactive isotope solution, with constant product yields achieved throughout the operation that were comparable to those reported for commercially available vessel-based synthesisers (40-80%). The system would allow researchers to obtain radiopharmaceuticals in a dose-on-demand setting within a few minutes. The flexible architecture of the platform, based on a modular design, can potentially be applied to the synthesis of other radiotracers that require a two-step synthetic approach, and may be adaptable to more complex synthetic routes by implementing additional modules. It can therefore be employed for standard synthesis protocols as well as for research and development of new radiopharmaceuticals.

引用

页码：2328 / 2336

页数：9

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