Sesquiterpenoids from Homalomena occulta affect osteoblast proliferation, differentiation and mineralization in vitro

被引：48

作者：

Hu, Yong-Mei ^{[1
,2
]}

Liu, Chuan ^{[3
]}

Cheng, Ka-Wing ^{[4
]}

Sung, Herman H. -Y. ^{[5
]}

Williams, Lan D. ^{[5
]}

Yang, Zhong-Lin ^{[1
]}

Ye, Wen-Cai ^{[2
]}

机构：

[1] China Pharmaceut Univ, Dept Tradit Chinese Med, Nanjing 210009, Peoples R China

[2] China Pharmaceut Univ, Dept Phytochem, Nanjing 210009, Peoples R China

[3] Nat Herbal Farm Inc, New York, NY 10017 USA

[4] Univ Hong Kong, Dept Bot, Hong Kong, Hong Kong, Peoples R China

[5] Hong Kong Univ Sci & Technol, Dept Chem, Hong Kong, Peoples R China

来源：

PHYTOCHEMISTRY | 2008年 / 69卷 / 12期

关键词：

Homalomena occulta (Lours); aracea; sesquiterpenoid; proliferation; differentiation; mineralization; osteoblasts;

D O I：

10.1016/j.phytochem.2008.05.023

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Chemical investigation of rhizomes of Homalomena occulta (Lours) resulted in isolation and identification of two sesquiterpenoids (6,7), and one daucane ester 8, together with five known sesquiterpenoids, oplodiol, oplopanone, homalomenol C, bullatantriol, and 1 beta,4 beta,7 alpha-trihydroxyeudesmane. Their structures were elucidated using 1D and 2D NMR spectroscopic and X-ray analyses. The chloroform extract of this plant and compounds 1-7 were tested in vitro for their activities in stimulating osteoblast (013) proliferation, differentiation and mineralization. Compounds 1-4 had a stimulative effect on significantly proliferation and differentiation of culture osteoblasts, while the chloroform extract and 1 significantly stimulated mineralization of cultured osteoblasts in vitro. (C) 2008 Published by Elsevier Ltd.

引用

页码：2367 / 2373

页数：7

共 14 条

[1]

Brixen KT, 2004, BASIC CLIN PHARMACOL, V94, P260

[2]

Chen Y. Z., 1986, SEPU, V4, P324

[3] TREATMENT OF POSTMENOPAUSAL OSTEOPOROSIS WITH A COMBINATION OF GROWTH-HORMONE AND PAMIDRONATE - A PLACEBO-CONTROLLED TRIAL [J].

ERDTSIECK, RJ ;

POLS, HAP ;

VALK, NK ;

VANOUWERKERK, BM ;

LAMBERTS, SWJ ;

MULDER, P ;

BIRKENHAGER, JC .

CLINICAL ENDOCRINOLOGY, 1995, 43 (05) :557-565

[4]

GUO SQ, 1998, ZHONGGUO GUZHI SHUSO, V18, P84

[5]

IZBOSAROV MB, 1998, CHEM NAT COMPD, V34, P289

[6]

LI FF, 1998, ZHONGGUO GUZHI SHUSO, V4, P71

[7]

MENEZES JES, 2004, J BIOSCI C, V59, P19

[8] BISABOLENE AND GUAIANE SESQUITERPENES FROM PULICARIA-GLUTINOSA [J].

MOSSA, JS ;

MUHAMMAD, I ;

ELFERALY, FS ;

HUFFORD, CD ;

MCPHAIL, DR ;

MCPHAIL, AT .

PHYTOCHEMISTRY, 1992, 31 (02) :575-578

[9] ISOLATION OF ALPHA-CORYMBOLOL, AN EUDESMANE SESQUITERPENE DIOL FROM CYPERUS-ARTICULATUS [J].

NYASSE, B ;

TIH, RG ;

SONDENGAM, BL ;

MARTIN, MT ;

BODO, B .

PHYTOCHEMISTRY, 1988, 27 (01) :179-181

[10] SESQUITERPENOIDS FROM THE ROOTS OF HOMALOMENA-AROMATICA [J].

SUNG, TV ;

STEFFAN, B ;

STEGLICH, W ;

KLEBE, G ;

ADAM, G .

PHYTOCHEMISTRY, 1992, 31 (10) :3515-3520

← 1 2 →