Microfluidic models of the human circulatory system: versatile platforms for exploring mechanobiology and disease modeling

被引：24
|
作者：
Nguyen, Ngan [1 ]
Thurgood, Peter [1 ]
Sekar, Nadia Chandra [2 ]
Chen, Sheng [1 ]
Pirogova, Elena [1 ]
Peter, Karlheinz [3 ,4 ]
Baratchi, Sara [2 ]
Khoshmanesh, Khashayar [1 ]
机构：
[1] RMIT Univ, Sch Engn, Melbourne, Australia
[2] RMIT Univ, Sch Hlth & Biomed Sci, Bundoora, Australia
[3] Baker Heart & Diabet Inst, Melbourne, Australia
[4] Univ Melbourne, Dept Cardiometab Hlth, Parkville, Australia
来源：
BIOPHYSICAL REVIEWS | 2021年 / 13卷 / 05期
基金：
澳大利亚研究理事会; 英国医学研究理事会; 澳大利亚国家健康与医学研究理事会;
关键词：
Microfluidics; Organ-on-a-chip; Human circulatory system; Cardiovascular diseases; Mechanobiology; BLOOD-BRAIN-BARRIER; WALL SHEAR RATE; MECHANICAL STIMULATION; PLATELET-AGGREGATION; BIOMIMETIC MODEL; ANIMAL-MODELS; FLOW; HEART; CHIP; DEVICE;
D O I：
10.1007/s12551-021-00815-8
中图分类号：
Q6 [生物物理学];
学科分类号：
071011 ;
摘要：
The human circulatory system is a marvelous fluidic system, which is very sensitive to biophysical and biochemical cues. The current animal and cell culture models do not recapitulate the functional properties of the human circulatory system, limiting our ability to fully understand the complex biological processes underlying the dysfunction of this multifaceted system. In this review, we discuss the unique ability of microfluidic systems to recapitulate the biophysical, biochemical, and functional properties of the human circulatory system. We also describe the remarkable capacity of microfluidic technologies for exploring the complex mechanobiology of the cardiovascular system, mechanistic studying of cardiovascular diseases, and screening cardiovascular drugs with the additional benefit of reducing the need for animal models. We also discuss opportunities for further advancement in this exciting field.
引用
收藏
页码：769 / 786
页数：18
相关论文
共 50 条
  • [41] Development of human skin spheroid system for psoriatic disease modeling and drug development
    Guo, Z.
    Jackow, J.
    Zeng, W.
    Hansen, C.
    Delorenzo, D.
    Hayashi, R.
    Abaci, H. E.
    Shin, J.
    Christiano, A.
    JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2019, 139 (05) : S180 - S180
  • [42] Pathology of inflammatory diseases of the nervous system: Human disease versus animal models
    Lassmann, Hans
    GLIA, 2020, 68 (04) : 830 - 844
  • [43] Engineering the next generation of human skeletal muscle models: From cellular complexity to disease modeling
    Moyle, Louise A.
    Jacques, Erik
    Gilbert, Penney M.
    CURRENT OPINION IN BIOMEDICAL ENGINEERING, 2020, 16 : 9 - 18
  • [44] Modeling Dynamic Human Behavioral Changes in Animal Disease Models: Challenges and Opportunities for Addressing Bias
    Hidano, Arata
    Enticott, Gareth
    Christley, Robert M.
    Gates, M. Carolyn
    FRONTIERS IN VETERINARY SCIENCE, 2018, 5
  • [45] Innovative Approach to Convert Geographic Information System-Based Highway Models into Multidimensional Building Information Modeling Platforms Using Dynamo
    Hu, Xiaoqiang
    Jiang, Yi
    Li, Shuo
    TRANSPORTATION RESEARCH RECORD, 2024, 2678 (08) : 637 - 659
  • [46] Elementary Students' Modeling Using Analogy Models to Reveal the Hidden Mechanism of the Human Respiratory System
    Han, Moonhyun
    Kim, Heui-baik
    INTERNATIONAL JOURNAL OF SCIENCE AND MATHEMATICS EDUCATION, 2019, 17 (05) : 923 - 942
  • [47] Elementary Students’ Modeling Using Analogy Models to Reveal the Hidden Mechanism of the Human Respiratory System
    Moonhyun Han
    Heui-baik Kim
    International Journal of Science and Mathematics Education, 2019, 17 : 923 - 942
  • [48] Modeling Gene Editing Outcomes in Microphysiological Human Tissue System Models of Duchenne Muscular Dystrophy
    Sitton, Madeleine J.
    Khodabukus, Alastair
    Bohning, Joel D.
    Bursac, Nenad
    Gersbach, Charles A.
    MOLECULAR THERAPY, 2023, 31 (04) : 65 - 65
  • [49] Generation of a 3D human neural system for Parkinson's disease modeling
    Qiu, B.
    Catala, P.
    Papadimou, E.
    Malpartida, A. B.
    Pappa, V.
    Kakava, S.
    Rendina, A.
    Caiazzo, M.
    HUMAN GENE THERAPY, 2018, 29 (12) : A97 - A97
  • [50] Modeling Human Nonalcoholic Fatty Liver Disease (NAFLD) with an Organoids-on-a-Chip System
    Wang, Yaqing
    Wang, Hui
    Deng, Pengwei
    Tao, Tingting
    Liu, Haitao
    Wu, Shuo
    Chen, Wenwen
    Qin, Jianhua
    ACS BIOMATERIALS SCIENCE & ENGINEERING, 2020, 6 (10) : 5734 - 5743
12345