Microfluidic models of the human circulatory system: versatile platforms for exploring mechanobiology and disease modeling

被引：24
|
作者：
Nguyen, Ngan [1 ]
Thurgood, Peter [1 ]
Sekar, Nadia Chandra [2 ]
Chen, Sheng [1 ]
Pirogova, Elena [1 ]
Peter, Karlheinz [3 ,4 ]
Baratchi, Sara [2 ]
Khoshmanesh, Khashayar [1 ]
机构：
[1] RMIT Univ, Sch Engn, Melbourne, Australia
[2] RMIT Univ, Sch Hlth & Biomed Sci, Bundoora, Australia
[3] Baker Heart & Diabet Inst, Melbourne, Australia
[4] Univ Melbourne, Dept Cardiometab Hlth, Parkville, Australia
来源：
BIOPHYSICAL REVIEWS | 2021年 / 13卷 / 05期
基金：
澳大利亚研究理事会; 英国医学研究理事会; 澳大利亚国家健康与医学研究理事会;
关键词：
Microfluidics; Organ-on-a-chip; Human circulatory system; Cardiovascular diseases; Mechanobiology; BLOOD-BRAIN-BARRIER; WALL SHEAR RATE; MECHANICAL STIMULATION; PLATELET-AGGREGATION; BIOMIMETIC MODEL; ANIMAL-MODELS; FLOW; HEART; CHIP; DEVICE;
D O I：
10.1007/s12551-021-00815-8
中图分类号：
Q6 [生物物理学];
学科分类号：
071011 ;
摘要：
The human circulatory system is a marvelous fluidic system, which is very sensitive to biophysical and biochemical cues. The current animal and cell culture models do not recapitulate the functional properties of the human circulatory system, limiting our ability to fully understand the complex biological processes underlying the dysfunction of this multifaceted system. In this review, we discuss the unique ability of microfluidic systems to recapitulate the biophysical, biochemical, and functional properties of the human circulatory system. We also describe the remarkable capacity of microfluidic technologies for exploring the complex mechanobiology of the cardiovascular system, mechanistic studying of cardiovascular diseases, and screening cardiovascular drugs with the additional benefit of reducing the need for animal models. We also discuss opportunities for further advancement in this exciting field.
引用
收藏
页码：769 / 786
页数：18
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