Synthesis of a novel amino acid based dendrimer

被引：52

作者：

Mulders, SJE ^{[1
]}

Brouwer, AJ ^{[1
]}

vanderMeer, PGJ ^{[1
]}

Liskamp, RMJ ^{[1
]}

机构：

[1] UNIV UTRECHT,UTRECHT INST PHARMACEUT SCI,DEPT MED CHEM,NL-3508 TB UTRECHT,NETHERLANDS

来源：

TETRAHEDRON LETTERS | 1997年 / 38卷 / 04期

关键词：

D O I：

10.1016/S0040-4039(96)02358-1

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An easy accessible dendrimer monomer 3,5-bis(2-tert-butyloxycarbonyl aminoethoxy) benzoic acid methyl ester 1 was designed. The monomer was converted to both the ''surface'' and ''braching'' monomer in a versatile synthesis of a novel amino acid based dendrimer by the covergent method, using the well established and high-yielding BOP-peptide coupling method. (C) 1997, Elsevier Science Ltd. All rights reserved.

引用

页码：631 / 634

页数：4

共 40 条

[1]

BUHLEIER E, 1978, SYNTHESIS-STUTTGART, P155

[2] 1-HYDROXY-7-AZABENZOTRIAZOLE - AN EFFICIENT PEPTIDE COUPLING ADDITIVE [J].

CARPINO, LA .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1993, 115 (10) :4397-4398

[3]

CASTRO B, 1975, TETRAHEDRON LETT, V14, P1219

[4]

CASTRO B, 1989, Patent No. 8902361

[5] Asymmetric dihydroxylation enables rapid construction of chiral dendrimers based on 1,2-diols [J].

Chang, HT ;

Chen, CT ;

Kondo, T ;

Siuzdak, G ;

Sharpless, KB .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION IN ENGLISH, 1996, 35 (02) :182-186

[6] SYNTHESIS AND CHARACTERIZATION OF OPTICALLY-ACTIVE, HOMOCHIRAL DENDRIMERS [J].

CHOW, HF ;

FOK, LF ;

MAK, CC .

TETRAHEDRON LETTERS, 1994, 35 (21) :3547-3550

[7] OXYBENZOTRIAZOLE FREE PEPTIDE COUPLING REAGENTS FOR N-METHYLATED AMINO-ACIDS [J].

COSTE, J ;

FREROT, E ;

JOUIN, P ;

CASTRO, B .

TETRAHEDRON LETTERS, 1991, 32 (17) :1967-1970

[8]

Dandliker PJ, 1995, ANGEW CHEM INT EDIT, V34, P2725

[9]

DANDLIKER PJ, 1994, ANGEW CHEM INT EDIT, V33, P1739, DOI 10.1002/anie.199417391

[10]

De Brabander-van den Berg E.M.M., 1993, ANGEW CHEM INT EDIT, V105, P1370

← 1 2 3 4 →