Tumor microenvironment-oriented adaptive nanodrugs based on peptide self-assembly

被引:69
|
作者
Li, Shukun [1 ,3 ]
Zhang, Wenjia [2 ]
Xue, Huadan [2 ]
Xing, Ruirui [1 ]
Yan, Xuehai [1 ,3 ]
机构
[1] Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, Beijing 100190, Peoples R China
[2] Peking Union Med Coll Hosp, Dept Radiol, Beijing 100730, Peoples R China
[3] Univ Chinese Acad Sci, Sch Chem Engn, Beijing 100049, Peoples R China
基金
中国国家自然科学基金;
关键词
PHOTODYNAMIC THERAPY; SUPRAMOLECULAR HYDROGELS; EMERGING APPLICATIONS; BETA-SHEET; PH; DELIVERY; NANOPARTICLES; CONJUGATE; VACCINE; NANOMATERIALS;
D O I
10.1039/d0sc02937h
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
The aberrant metabolism of tumor cells creates an inimitable microenvironment featuring acidic pH, high glutathione (GSH) levels, and overexpression of certain enzymes, which benefits the overwhelming progress of a tumor. Peptide self-assembly, emerging as a biofriendly and versatile fabrication strategy, harnesses multiple noncovalent interactions to obtain a variety of nanostructures tailored on demand. Orchestrating the reversible nature of noncovalent interactions and abnormal physiological parameters in the tumor microenvironment enables peptide-based nanodrugs to be targetable or switchable, thereby improving the drugs' bioavailability and optimizing the treatment outcome. This review will focus on peptide-modulated self-assembly of photosensitizers, chemotherapeutic drugs, immunoactive agents for tumor microenvironment-oriented adaptive phototherapy, chemotherapy, immunotherapy and combinatorial therapy. We will emphasize the building block design, the intermolecular interaction principle, adaptive structural transformation in the tumor microenvironment and corresponding therapeutic efficacy, and aim to elucidate the critical role of peptide-modulated, tumor microenvironment-oriented adaptive assemblies in improving the therapeutic index. Challenges and opportunities will be covered as well to advance the development and clinical application of tumor therapies based on peptide self-assembly materials and techniques.
引用
收藏
页码:8644 / 8656
页数:13
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