Controllable synthesis of Gd2O(CO3)2•H2O@silica-FITC nanoparticles with size-dependent optical and magnetic resonance imaging properties

被引：15

作者：

Zhou, Liangjun ^{[1
,2
]}

Yin, Wenyan ^{[1
]}

Ren, Wenlu ^{[1
]}

Gu, Zhanjun ^{[1
]}

Li, Wei ^{[1
]}

Jin, Shan ^{[1
,2
]}

Yan, Liang ^{[1
]}

Tian, Gan ^{[1
,3
]}

Hu, Zhongbo ^{[2
]}

Zhao, Yuliang ^{[1
,4
]}

机构：

[1] Chinese Acad Sci, Key Lab Biomed Effects Nanomat & Nanosafety, Inst High Energy Phys, Beijing 100049, Peoples R China

[2] Univ Chinese Acad Sci, Coll Mat Sci & Optoelect Technol, Beijing 100049, Peoples R China

[3] Sichuan Univ, Coll Chem, Chengdu 610064, Peoples R China

[4] Natl Ctr Nanosci & Technol China, Key Lab Biomed Effects Nanomat & Nanosafety, Beijing 100190, Peoples R China

来源：

NEW JOURNAL OF CHEMISTRY | 2012年 / 36卷 / 12期

基金：

中国国家自然科学基金;

关键词：

IRON-OXIDE NANOPARTICLES; SILICA NANOPARTICLES; CONTRAST AGENT; FLUORESCENCE; SURFACE; CYTOTOXICITY; NANOCRYSTALS; RELAXIVITY; DELIVERY; GD2O3;

D O I：

10.1039/c2nj40431a

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Gadolinium carbonate (Gd2O(CO3)(2)center dot H2O) nanoparticles (NPs) with different diameters (from 280 nm to 10 nm) were obtained through a simple hydrothermal process by adding different volumes of glycerol. These Gd2O(CO3)(2)center dot H2O NPs were further coated with a thin layer of silica containing fluorescent dye (fluorescein isothiocyanate, FITC), and the possibility of using these NPs for optical imaging was demonstrated. In addition, due to the presence of Gd3+ ions on the surface of the NPs, magnetic resonance imaging (MRI) of Gd2O(CO3)(2)center dot H2O NPs with different diameters was also reported in detail. Considering the effect of NPs' size on their biocompatibility and MRI properties, our research results indicated that the Gd2O(CO3)(2)center dot H2O NPs of 50 nm showed the highest cytotoxicity and the maximum uptake by cells, and the MRI properties of Gd2O(CO3)(2)center dot H2O@silica-FITC NPs are also size-dependent. Therefore, these NPs exhibit bifunctionality for both optical imaging and MRI, making them potentially applicable in the biomedical field.

引用

页码：2599 / 2606

页数：8

共 38 条

[1] Quantum dot - Aptamer conjugates for synchronous cancer imaging, therapy, and sensing of drug delivery based on Bi-fluorescence resonance energy transfer [J].