Aflatoxin B1-Induced Reproductive Toxicity in Male Rats: Possible Mechanism of Action

被引：59

作者：

Supriya, Ch. ^{[1
]}

Girish, B. P. ^{[1
,2
]}

Reddy, P. Sreenivasula ^{[2
]}

机构：

[1] Sri Venkateswara Univ, Dept Biotechnol, Tirupati 517502, Andhra Pradesh, India

[2] Sri Venkateswara Univ, Dept Zool, Tirupati 517502, Andhra Pradesh, India

来源：

INTERNATIONAL JOURNAL OF TOXICOLOGY | 2014年 / 33卷 / 03期

关键词：

aflatoxin B1; steroidogenesis; spermatogenesis; serum testosterone; StAR; hydroxysteroid dehydrogenases; STEROIDOGENESIS; EXPOSURE; HORMONE; TESTOSTERONE; EPIDIDYMIS; PROFILES; GROWTH; CELLS; B-1; FSH;

D O I：

10.1177/1091581814530764

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Aflatoxin B1 (AFB1), one of the most common mycotoxins found in human foods, is principally hepatotoxic; however, it also affects reproduction. The aim of the present study was to elucidate the reproductive toxic effects and possible mechanism of action of AFB1 in rats. Male Wistar rats were injected intramuscularly with doses of 10, 20, or 50 mu g AFB1/kg body weight on alternate days from 45 to 100 days of age. Significant reductions in body weights, relative weights of reproductive organs, daily sperm production, epididymal sperm count, viable sperm, motile sperm, and hypoosmotic swelling-tail coiled sperm were observed. Significant decreases in testicular steroidogenic enzymes and serum testosterone levels were also observed indicating decreased steroidogenesis. In silico docking studies illustrated AFB1 binds with steroidogenic acute regulatory (StAR) protein thereby affecting the transport of cholesterol into mitochondria resulting in decreased steroidogenesis.

引用

页码：155 / 161

页数：7

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