White-matter functional networks changes in patients with schizophrenia

被引：109

作者：

Jiang, Yuchao ^{[1
]}

Luo, Cheng ^{[1
]}

Li, Xuan ^{[1
]}

Li, Yingjia ^{[1
]}

Yang, Hang ^{[1
]}

Li, Jianfu ^{[1
]}

Chang, Xin ^{[1
]}

Li, Hechun ^{[1
]}

Yang, Huanghao ^{[1
]}

Wang, Jijun ^{[2
]}

Duan, Mingjun ^{[1
,3
]}

Yao, Dezhong ^{[1
]}

机构：

[1] Univ Elect Sci & Technol China, Sch Life Sci & Technol, Ctr Informat Med, Clin Hosp,Chengdu Brain Sci Inst,MOE Key Lab Neur, Chengdu 610054, Sichuan, Peoples R China

[2] Shanghai Jiao Tong Univ, Sch Med, Shanghai Mental Hlth Ctr, Shanghai Key Lab Psychot Disorders, Shanghai 200030, Peoples R China

[3] Chengdu Mental Hlth Ctr, Dept Psychiat, Chengdu 610054, Sichuan, Peoples R China

来源：

NEUROIMAGE | 2019年 / 190卷

关键词：

White-matter functional network; Schizophrenia; Resting-state functional connectivity; fMRI; BRAIN ACTIVITY; ORGANIZATION; CONNECTIVITY; FLUCTUATIONS; CORTEX; REST;

D O I：

10.1016/j.neuroimage.2018.04.018

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Resting-state functional MRI (rsfMRI) is a useful technique for investigating the functional organization of human gray-matter in neuroscience and neuropsychiatry. Nevertheless, most studies have demonstrated the functional connectivity and/or task-related functional activity in the gray-matter. White-matter functional networks have been investigated in healthy subjects. Schizophrenia has been hypothesized to be a brain disorder involving insufficient or ineffective communication associated with white-matter abnormalities. However, previous studies have mainly examined the structural architecture of white-matter using MRI or diffusion tensor imaging and failed to uncover any dysfunctional connectivity within the white-matter on rsfMRI. The current study used rsfMRI to evaluate white-matter functional connectivity in a large cohort of ninety-seven schizophrenia patients and 126 healthy controls. Ten large-scale white-matter networks were identified by a cluster analysis of voxel-based white-matter functional connectivity and classified into superficial, middle and deep layers of networks. Evaluation of the spontaneous oscillation of white-matter networks and the functional connectivity between them showed that patients with schizophrenia had decreased amplitudes of low-frequency oscillation and increased functional connectivity in the superficial perception-motor networks. Additionally, we examined the interactions between white-matter and gray-matter networks. The superficial perception-motor white-matter network had decreased functional connectivity with the cortical perception-motor gray-matter networks. In contrast, the middle and deep white-matter networks had increased functional connectivity with the superficial perception-motor white-matter network and the cortical perception-motor gray-matter network. Thus, we presumed that the disrupted association between the gray-matter and white-matter networks in the perception-motor system may be compensated for through the middle-deep white-matter networks, which may be the foundation of the extensively disrupted connections in schizophrenia.

引用

页码：172 / 181

页数：10

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