Intratumoral microdistribution of [I-131]MB-1 in patients with B-cell lymphoma following radioimmunotherapy

被引：15
作者：
Brown, RS
Kaminski, MS
Fisher, SJ
Chang, AE
Wahl, RL
机构：
[1] UNIV MICHIGAN,MED CTR,DEPT RADIOL,ANN ARBOR,MI 48109
[2] UNIV MICHIGAN,MED CTR,DEPT SURG,ANN ARBOR,MI 48109
[3] UNIV MICHIGAN,MED CTR,DEPT INTERNAL MED,DIV NUCL MED,ANN ARBOR,MI 48109
[4] UNIV MICHIGAN,MED CTR,DEPT INTERNAL MED,DIV HEMATOL ONCOL,ANN ARBOR,MI 48109
来源：
NUCLEAR MEDICINE AND BIOLOGY | 1997年 / 24卷 / 07期
关键词：
lymphoma; human; radioimmunotherapy; monoclonal antibodies; autoradiography; pan-B cell;
D O I：
10.1016/S0969-8051(97)00099-1
中图分类号：
R8 [特种医学]; R445 [影像诊断学];
学科分类号：
1002 ; 100207 ; 1009 ;
摘要：
Intratumoral microdistribution of radiolabelled anti-CD37 murine monoclonal antibody, [I-131]MB-1, in lymph nodes from five patients with non-Hodgkin's B-cell lymphoma following radioimmunotherapy were evaluated by microautoradiography and image analysis of macroautoradiographs. Microdistribution of radioactivity was highly heterogeneous: silver grain counts varied from 28-70 to 8-10 per 400X field, and the coefficients of variations calculated by image analysis ranged between 42.5 and 79.3 %. Variable radiation doses delivered could have contributed to the limited durability of tumor regression. (C) 1997 Elsevier Science Inc.
引用
收藏
页码：657 / 663
页数：7
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