Intratumoral microdistribution of [I-131]MB-1 in patients with B-cell lymphoma following radioimmunotherapy

被引：15

作者：

Brown, RS

Kaminski, MS

Fisher, SJ

Chang, AE

Wahl, RL

机构：

[1] UNIV MICHIGAN,MED CTR,DEPT RADIOL,ANN ARBOR,MI 48109

[2] UNIV MICHIGAN,MED CTR,DEPT SURG,ANN ARBOR,MI 48109

[3] UNIV MICHIGAN,MED CTR,DEPT INTERNAL MED,DIV NUCL MED,ANN ARBOR,MI 48109

[4] UNIV MICHIGAN,MED CTR,DEPT INTERNAL MED,DIV HEMATOL ONCOL,ANN ARBOR,MI 48109

来源：

NUCLEAR MEDICINE AND BIOLOGY | 1997年 / 24卷 / 07期

关键词：

lymphoma; human; radioimmunotherapy; monoclonal antibodies; autoradiography; pan-B cell;

D O I：

10.1016/S0969-8051(97)00099-1

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

Intratumoral microdistribution of radiolabelled anti-CD37 murine monoclonal antibody, [I-131]MB-1, in lymph nodes from five patients with non-Hodgkin's B-cell lymphoma following radioimmunotherapy were evaluated by microautoradiography and image analysis of macroautoradiographs. Microdistribution of radioactivity was highly heterogeneous: silver grain counts varied from 28-70 to 8-10 per 400X field, and the coefficients of variations calculated by image analysis ranged between 42.5 and 79.3 %. Variable radiation doses delivered could have contributed to the limited durability of tumor regression. (C) 1997 Elsevier Science Inc.

引用

页码：657 / 663

页数：7

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