The crack nucleation behavior of rough surfaces in line contact is investigated by means of a thermodynamically based continuum damage mechanics technique. The deterministic approach is employed to investigate the effect of roughness on the surface tractions and contact stresses. In order to treat the effect of high stress gradients, a special averaging technique, proposed previously for the case of smooth surface, is adopted in this study. The predictions of the crack nucleation life are compared with the relevant experimental data in the literature and indicate the validity of the analysis.