Polyarteritis Nodosa Neurologic Manifestations

被引：37

作者：

de Boysson, Hubert ^{[1
]}

Guillevin, Loic ^{[2
]}

机构：

[1] Univ Caen, Dept Internal Med, Ctr Hosp, Caen, France

[2] Univ Paris 05, Vasculitides & Scleroderma, Referral Ctr Rare Autoimmune & Syst Dis, Dept Internal Med,Hop Cochin, 27 Rue Fg St Jacques, F-75679 Paris 14, France

来源：

NEUROLOGIC CLINICS | 2019年 / 37卷 / 02期

关键词：

Polyarteritis nodosa; Peripheral neuropathy; Vasculitis; ANCA; Stroke; Hepatitis B virus; SYSTEMIC-NECROTIZING-VASCULITIDES; CHURG-STRAUSS-SYNDROME; POOR-PROGNOSIS FACTORS; TERM-FOLLOW-UP; MICROSCOPIC POLYANGIITIS; NERVOUS-SYSTEM; PERIPHERAL NEUROPATHY; RANDOMIZED-TRIAL; FEATURES; GRANULOMATOSIS;

D O I：

10.1016/j.ncl.2019.01.007

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Polyarteritis nodosa (PAN) is a necrotizing vasculitis affecting medium-sized vessels whose main manifestations are weight loss, fever, peripheral neuropathy, renal, musculoskeletal, gastrointestinal tract and/or cutaneous involvement(s), hypertension and/or cardiac failure. Peripheral neuropathy is one of the most frequent and earliest symptoms, affecting 50% to 75% of PAN patients. Central nervous system involvement affects only 2% to 10% of PAN patients, often late during the disease course. Treatment relies on combining corticosteroids and an immunosuppressant (mainly cyclophosphamide) in patients with poor prognoses. In patients with hepatitis B virus-related PAN, plasma exchanges and antiviral drugs should be combined with corticosteroids.

引用

页码：345 / +

页数：15

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