Genes of type 2 diabetes in β cells

被引：12
作者：
Trajkovski, Mirko [1 ]
Mziaut, Hassan [1 ]
Schwarz, Peter E. [1 ]
Solimena, Michele [1 ]
机构：
[1] Tech Univ Dresden, Carl Gustav Carus Med Sch, Med Clin 3, D-01307 Dresden, Germany
来源：
ENDOCRINOLOGY AND METABOLISM CLINICS OF NORTH AMERICA | 2006年 / 35卷 / 02期
关键词：
D O I：
10.1016/j.ecl.2006.02.008
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Type 2 diabetes is a complex polygenic metabolic disorder of epidemic proportions. This review provides a brief overview of the susceptibility genes in type 2 diabetes that primarily affect pancreatic P cells, with emphasis on their function and most relevant polymorphisms. We focus on calpain 10, the only susceptibility gene identified thus far through a positional cloning approach in subjects with diabetes.
引用
收藏
页码：357 / +
页数：14
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