Micafungin for Candida Albicans Pacemaker-Associated Endocarditis: A Case Report and Review of the Literature

被引：15

作者：

Tascini, Carlo ^{[1
]}

Bongiorni, Maria Grazia ^{[2
]}

Tagliaferri, Enrico ^{[1
,3
]}

Di Paolo, Antonello ^{[4
]}

Flammini, Sarah ^{[1
]}

Soldati, Ezio ^{[2
]}

Leonildi, Alessandro ^{[1
]}

Di Cori, Andrea ^{[2
]}

Menichetti, Francesco ^{[1
]}

机构：

[1] Azienda Osped Univ Pisana, UO Malattie Infett, Pisa, Italy

[2] Azienda Osped Univ Pisana, UO Cardiol 2, Pisa, Italy

[3] Nuovo Santa Chiara Hosp, UO Malattie Infett, I-56100 Pisa, Italy

[4] Univ Pisa, Div Farmacol & Chemioterapia, Pisa, Italy

来源：

MYCOPATHOLOGIA | 2013年 / 175卷 / 1-2期

关键词：

Micafungin; Candida; Endocarditis; Pacemaker; IN-VITRO ACTIVITY; ANTIFUNGAL COMBINATIONS; SURGICAL-MANAGEMENT; PERMANENT PACEMAKER; DEVICE INFECTIONS; AMPHOTERICIN-B; EXTRACTION; BIOFILMS; CASPOFUNGIN; SOCIETY;

D O I：

10.1007/s11046-012-9591-2

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

We report on the treatment with micafungin of a pacemaker-associated endocarditis due to Candida albicans. Antifungal therapy was able to reduce vegetation size from 5 to 1 cm making possible the transvenous removal of the device without a high risk of pulmonary embolism. Noteworthy, a high micafungin concentration was documented into the lead vegetation (10 mu g/g of vegetation tissue) and this may have contributed to the striking size reduction of vegetation.

引用

页码：129 / 134

页数：6

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