Gβγ recruits heterodimeric phosphatidylinositide 3-kinase γ to the cell membrane through interaction with its non-catalytic p101-subunit

被引:0
|
作者
Brock, C
Schaefer, M
Czupalla, C
Reusch, HP
Schulz, A
Nürnberg, B
机构
[1] Free Univ Berlin, Inst Pharmakol, D-14195 Berlin, Germany
[2] Free Univ Berlin, Klin Pharmakol, D-14195 Berlin, Germany
[3] Univ Ulm, Abt Pharmakol & Toxikol, D-89081 Ulm, Germany
关键词
D O I
暂无
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
169
引用
收藏
页码:R46 / R46
页数:1
相关论文
共 23 条
  • [1] Role of non-catalytic p101 subunit in regulation of phosphoinositide 3-kinase γ enzymatic activities
    Shymanets, A.
    Ahmadian, M. R.
    Nuernberg, B.
    NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, 2008, 377 : 25 - 25
  • [2] The role of non-catalytic p101 and p87 subunits in regulating phosphoinositide 3-kinase γ by Gβγ and H-Ras
    Shymanets, A.
    Ahmadian, M. R.
    Krause, E.
    Wetzker, R.
    Harteneck, C.
    Nuernberg, B.
    NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, 2012, 385 : 88 - 89
  • [3] The phosphoinositide-3-kinase p101 subunit facilitates membrane translocation of PI3K allowing direct interaction of Gβγ with the catalytic p110γ subunit
    Leopoldt, D
    Maier, U
    Exner, T
    Nürnberg, B
    NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, 1998, 358 (01) : R657 - R657
  • [4] Roles of non-catalytic subunits in Gβγ-induced activation of class I phosphoinositide 3-kinase isoforms β and γ
    Maier, U
    Babich, A
    Nürnberg, B
    JOURNAL OF BIOLOGICAL CHEMISTRY, 1999, 274 (41) : 29311 - 29317
  • [5] Roles of Non-catalytic Subunits in Gβγ-induced Activation of Class I Phosphoinositide 3-Kinase Isoforms β and γ
    Maier, Udo
    Babich, Aleksei
    Nurnberg, Bernd
    Journal of Biological Chemistry, 274 (41): : 29311 - 29317
  • [6] Inhibition of p85, the non-catalytic subunit of phosphatidylinositol 3-kinase, exerts potent antitumor activity in human breast cancer cells
    Folgiero, V.
    Di Carlo, S. E.
    Bon, G.
    Spugnini, E. P.
    Di Benedetto, A.
    Germoni, S.
    Gentileschi, M. Pia
    Accardo, A.
    Milella, M.
    Morelli, G.
    Bossi, G.
    Mottolese, M.
    Falcioni, R.
    CELL DEATH & DISEASE, 2012, 3 : e440 - e440
  • [7] Inhibition of p85, the non-catalytic subunit of phosphatidylinositol 3-kinase, exerts potent antitumor activity in human breast cancer cells
    V Folgiero
    S E Di Carlo
    G Bon
    E P Spugnini
    A Di Benedetto
    S Germoni
    M Pia Gentileschi
    A Accardo
    M Milella
    G Morelli
    G Bossi
    M Mottolese
    R Falcioni
    Cell Death & Disease, 2012, 3 : e440 - e440
  • [8] Roles of Gβγ in membrane recruitment and activation of p110γ/p101 phosphoinositide 3-kinase γ
    Brock, C
    Schaefer, M
    Reusch, HP
    Czupalla, C
    Michalke, M
    Spicher, K
    Schultz, G
    Nürnberg, B
    JOURNAL OF CELL BIOLOGY, 2003, 160 (01): : 89 - 99
  • [9] Non-catalytic role of phosphoinositide 3-kinase in mesenchymal cell migration through non-canonical induction of p85β/AP2-mediated endocytosis
    Matsubayashi, Hideaki T.
    Mountain, Jack
    Takahashi, Nozomi
    Deb Roy, Abhijit
    Yao, Tony
    Peterson, Amy F.
    Gonzalez, Cristian Saez
    Kawamata, Ibuki
    Inoue, Takanari
    NATURE COMMUNICATIONS, 2024, 15 (01)
  • [10] Non-catalytic role of phosphoinositide 3-kinase in mesenchymal cell migration through non-canonical induction of p85β/AP2-mediated endocytosis
    Hideaki T. Matsubayashi
    Jack Mountain
    Nozomi Takahashi
    Abhijit Deb Roy
    Tony Yao
    Amy F. Peterson
    Cristian Saez Gonzalez
    Ibuki Kawamata
    Takanari Inoue
    Nature Communications, 15