Overexpression of SLC7A7 predicts poor progression-free and overall survival in patients with glioblastoma

被引：21

作者：

Fan, Songhua ^{[1
]}

Meng, Delong ^{[2
,3
]}

Xu, Tao ^{[4
]}

Chen, Yuanyuan ^{[2
,3
]}

Wang, Jingkun ^{[2
,3
]}

Li, Xiaoying ^{[2
,3
]}

Chen, Hongyan ^{[2
,3
]}

Lu, Daru ^{[2
,3
]}

Chen, Juxiang ^{[4
]}

Lan, Qing ^{[1
]}

机构：

[1] Soochow Univ, Dept Neurosurg, Affiliated Hosp 2, Suzhou, Peoples R China

[2] Fudan Univ, State Key Lab Genet Engn, Fudan VARI Genet Epidemiol Ctr, Shanghai 200433, Peoples R China

[3] Fudan Univ, MOE Key Lab Contemporary Anthropol, Sch Life Sci, Shanghai 200433, Peoples R China

[4] Second Mil Med Univ, Changzheng Hosp, Dept Neurosurg, Shanghai, Peoples R China

来源：

MEDICAL ONCOLOGY | 2013年 / 30卷 / 01期

关键词：

Glioblastoma (GBM); SLC7A7; Overexpression; Prognostic significance; LYMPH-NODE METASTASIS; AMINO-ACID-TRANSPORT; PANCREATIC-CANCER; LUNG-CANCER; GENE; CHEMOTHERAPY; PATHWAYS; BEHAVIOR; TUMORS; TRIAL;

D O I：

10.1007/s12032-012-0384-8

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The clinical significance of SLC7A7 expression remains unclear. In this study, we aimed to explore whether SLC7A7 expression in tumor tissues could be used to assess subsequent prognosis in patients with glioblastoma (GBM). A total of 119 patients with pathologically confirmed GBM and 16 normal controls were recruited for this study. The expression of SLC7A7 in GBM and normal tissues was evaluated by immunohistochemistry in tissue microarrays and quantitative real-time PCR. Kaplan-Meier method and Cox's proportional hazards model were used in survival analysis. Compared with normal tissues, GBM specimens had significantly increased expression of SLC7A7 at both mRNA and protein levels (both P < 0.05). Moreover, multivariate analysis confirmed that overexpression of SLC7A7 was a significant and independent indicator for predicting poor prognosis. Our results suggest, for the first time, that overexpression of SLC7A7 is correlated with worse outcomes in patients with GBM. SLC7A7 plays a critical role in GBM carcinogenesis and may be a potential prognosis predictor of GBM.

引用

页数：7

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