Comparative in vitro activities of ciprofloxacin, clinafloxacin, gatifloxacin, levofloxacin, moxifloxacin, and trovafloxacin against Klebsiella pneumoniae, Klebsiella oxytoca, Enterobacter cloacae, and Enterobacter aerogenes clinical isolates with alterations in GyrA and ParC proteins

被引：41
作者：
Brisse, S
Milatovic, D
Fluit, AC
Verhoef, J
Martin, N
Scheuring, S
Köhrer, K
Schmitz, FJ
机构：
[1] Univ Utrecht, Eijkman Winkler Inst, NL-3584 CX Utrecht, Netherlands
[2] Univ Hosp Dusseldorf, Inst Med Microbiol & Virol, D-40225 Dusseldorf, Germany
来源：
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 1999年 / 43卷 / 08期
关键词：
D O I：
10.1128/AAC.43.8.2051
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
The in vitro activities of ciprofloxacin, clinafloxacin, gatifloxacin, levofloxacin, moxifloxacin, and trovafloxacin were tested against 72 ciprofloxacin-resistant and 28 ciprofloxacin-susceptible isolates of Klebsiella pneumoniae, Klebsiella oxytoca, Enterobacter cloacae, and Enterobacter aerogenes. Irrespective of the alterations in GyrA and ParC proteins, clinafloxacin exhibited greater activity than all other fluoroquinolones tested against K. pneumoniae and E. aerogenes.
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页码：2051 / 2055
页数：5
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