Porous Three-Dimensional PVA/Gelatin Sponge for Skin Tissue Engineering

被引：70

作者：

Choi, Soon Mo ^{[1
,2
]}

Singh, Deepti ^{[1
,2
,3
]}

Kumar, Ashok ^{[3
]}

Oh, Tae Hwan ^{[1
,2
]}

Cho, Yong Woo ^{[4
]}

Han, Sung Soo ^{[1
,2
]}

机构：

[1] Yeungnam Univ, Sch Engn, Dept Nano Med & Polymer Mat, Gyongsan 712749, Gyeonsangbukdo, South Korea

[2] Yeungnam Univ, Polymer Gel Res Cluster Ctr, Gyongsan 712749, Gyeonsangbukdo, South Korea

[3] Indian Inst Technol Kanpur, Kanpur, Uttar Pradesh, India

[4] Hanyang Univ, Dept Chem Engn, Ansan, South Korea

来源：

INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS | 2013年 / 62卷 / 07期

关键词：

Compression; 3-D sponge; freeze-drying; gelatin; human fibroblast; PVA; skin tissue engineering;

D O I：

10.1080/00914037.2012.710862

中图分类号：

TB3 [工程材料学]; R318.08 [生物材料学];

学科分类号：

0805 ; 080501 ; 080502 ;

摘要：

A series of PVA/gelatin scaffolds in different concentrations were prepared and blended to evaluate the polymer concentration effects on the architecture of the scaffold. SEM images revealed that with increasing gelatin concentration the average pore diameters varied from 60 to 190nm. Bio-compatibility assay showed cells attached and elongated actively on the scaffolds and cyto-toxicity results of all samples were found to be in grade 1 or 0, indicating the bio-safety of PVA/gelatin as biomaterial. Results indicate the polymer concentration effects on the architecture of the scaffold and PVA/gelatin macroporous scaffolds have potential to be bio-matrices for tissue genesis.

引用

页码：384 / 389

页数：6

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