Kolaviron suppresses dysfunctional reproductive axis associated with multi-walled carbon nanotubes exposure in male rats

被引:4
作者
Adedara, Isaac Adegboyega [1 ]
Awogbindin, Ifeoluwa Oluleke [1 ]
Maduako, Ikenna Chukwuemeka [1 ]
Ajeleti, Akinola Olusegun [2 ]
Owumi, Solomon Eduviere [3 ]
Owoeye, Olatunde [4 ]
Patlolla, Anita Kumari [5 ]
Farombi, Ebenezer Olatunde [1 ]
机构
[1] Univ Ibadan, Coll Med, Dept Biochem, Drug Metab & Toxicol Res Labs, Ibadan, Nigeria
[2] Bowen Univ, Coll Med, Dept Anat, Iwo, Nigeria
[3] Univ Ibadan, Coll Med, Dept Biochem, Canc Res & Mol Biol Lab, Ibadan, Nigeria
[4] Univ Ibadan, Coll Med, Dept Anat, Ibadan, Nigeria
[5] Jackson State Univ, Coll Sci Engn & Technol, NIH RCMI Ctr Environm Hlth, Jackson, MS USA
关键词
Multi-walled carbon nanotubes; Reproductive axis; Kolaviron; Oxido-inflammation; Rats; GARCINIA-KOLA; OXIDATIVE STRESS; DEVELOPMENTAL TOXICITY; BIFLAVONOID COMPLEX; SEXUAL-BEHAVIOR; ANTIOXIDANT; GLUTATHIONE; HEPATOTOXICITY; NANOMATERIALS; INFLAMMATION;
D O I
10.1007/s11356-020-10324-y
中图分类号
X [环境科学、安全科学];
学科分类号
08 ; 0830 ;
摘要
Reproductive toxicity associated with excessive exposure to multi-walled carbon nanotubes (MWCNTs), which are commonly used in medicine as valuable drug delivery systems, is well documented. Kolaviron, a bioflavonoid isolated fromGarcinia kolaseeds, elicits numerous health beneficial effects related to its anti-inflammatory, anti-genotoxic activities, anti-apoptotic, and antioxidant properties. However, information on the role of kolaviron in MWCNTs-induced reproductive toxicity is not available in the literature. Herein, we assessed the protective effects of kolaviron on MWCNTs-induced dysfunctional reproductive axis in rats following exposure to MWCNTs (1 mg/kg) and concurrent treatment with kolaviron (50 or 100 mg/kg body weight) for 15 successive days. Results showed that MWCNTs-induced dysfunctional reproductive axis as evidenced by deficits in pituitary and testicular hormones, marker enzymes of testicular function, and sperm functional characteristics were abrogated in rats co-administered with kolaviron. Moreover, co-administration of kolaviron-abated MWCNTs-induced inhibition of antioxidant enzyme activities increases in oxidative stress and inflammatory indices. This is evidenced by diminished levels of tumor necrosis factor-alpha, nitric oxide, lipid peroxidation, reactive oxygen, and nitrogen species as well as reduced activity of myeloperoxidase in testes, epididymis, and hypothalamus of the rats. Biochemical data on the chemoprotection of MWCNTs-induced reproductive toxicity were corroborated by histological findings. Taken together, kolaviron suppressed dysfunctional reproductive axis associated with MWCNTs exposure via abrogation of oxidative stress and inflammation in male rats.
引用
收藏
页码:354 / 364
页数:11
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