Entrapped polyamines in biomimetically synthesized nanostructured silica spheres as pH-responsive gates for controlled drug release

被引：6

作者：

Begum, Gousia ^{[1
]}

Laxmi, M. Vijaya ^{[1
]}

Rana, Rohit Kumar ^{[1
]}

机构：

[1] Indian Inst Chem Technol, Inorgan & Phys Chem Div, Nanomat Lab, Hyderabad 500607, Andhra Pradesh, India

来源：

JOURNAL OF MATERIALS CHEMISTRY | 2012年 / 22卷 / 41期

关键词：

SOLID-STATE; PARTICLE-SIZE; DELIVERY; NANOPARTICLES; IBUPROFEN; MORPHOLOGY;

D O I：

10.1039/c2jm32898d

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

We report here a versatile pH-controlled drug delivery system utilizing the polyamine-mediated bioinspired mineralization approach. In a single step method suitably functionalized monodisperse mesoporous silica spheres (MMS) are obtained, which when encapsulated with ibuprofen, a nonsteroidal anti-inflammatory drug, lead to pH-responsive controlled release of the drug from the mesoporous channels. The polyamines that are responsible for the silicification process in turn act as molecular gates controlling the drug release in a pH dependent manner. Interestingly, while the presence of a polyamine prevents the drug from releasing out of the pores, its absence in MMS allows the drug to be released at a neutral pH.

引用

收藏

页码：22174 / 22180

页数：7

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