Increased dosage of the RUNX1/AML1 gene:: A third mode of RUNX leukemia?

被引：27

作者：

Osato, M ^{[1
]}

Ito, Y ^{[1
]}

机构：

[1] Natl Univ Singapore, Inst Mol & Cell Biol, Oncol Res Inst, Singapore 138673, Singapore

来源：

CRITICAL REVIEWS IN EUKARYOTIC GENE EXPRESSION | 2005年 / 15卷 / 03期

关键词：

RUNX; AML1; Down syndrome; trisomy; 21; megakaryocyte;

D O I：

10.1615/CritRevEukarGeneExpr.v15.i3.40

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

RUNX1/AML1, located on chromosome 21, is a key factor in the generation and maintenance of hematopoietic stem cells and the gene most frequently implicated in human leukemias. Chromosome translocations and point mutations are well-documented genetic alterations in RUNX leukemia (also known as CBF leukemia). In addition, overdosage or overexpression of RUNX1 is suspected to be a third mode of RUNX1 involvement in leukemogenesis. The possibility that this mode might underlie Down syndrome-related leukemias caused by trisomy of chromosome 21 is discussed.

引用

页码：217 / 228

页数：12

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