Increased dosage of the RUNX1/AML1 gene:: A third mode of RUNX leukemia?

被引：27
|
作者：
Osato, M [1 ]
Ito, Y [1 ]
机构：
[1] Natl Univ Singapore, Inst Mol & Cell Biol, Oncol Res Inst, Singapore 138673, Singapore
来源：
CRITICAL REVIEWS IN EUKARYOTIC GENE EXPRESSION | 2005年 / 15卷 / 03期
关键词：
RUNX; AML1; Down syndrome; trisomy; 21; megakaryocyte;
D O I：
10.1615/CritRevEukarGeneExpr.v15.i3.40
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
RUNX1/AML1, located on chromosome 21, is a key factor in the generation and maintenance of hematopoietic stem cells and the gene most frequently implicated in human leukemias. Chromosome translocations and point mutations are well-documented genetic alterations in RUNX leukemia (also known as CBF leukemia). In addition, overdosage or overexpression of RUNX1 is suspected to be a third mode of RUNX1 involvement in leukemogenesis. The possibility that this mode might underlie Down syndrome-related leukemias caused by trisomy of chromosome 21 is discussed.
引用
收藏
页码：217 / 228
页数：12
相关论文
共 50 条
  • [1] Point mutations in the RUNX1/AML1 gene: another actor in RUNX leukemia
    Motomi Osato
    Oncogene, 2004, 23 : 4284 - 4296
  • [2] Point mutations in the RUNX1/AML1 gene:: another actor in RUNX leukemia
    Osato, M
    ONCOGENE, 2004, 23 (24) : 4284 - 4296
  • [3] Runx1/AML1 and hematopoietic dysplasia
    Telfer, Janice C.
    Malcuit, Nancy
    Hedblom, Emmett
    Kane, Christyne
    JOURNAL OF IMMUNOLOGY, 2007, 178
  • [4] Identification of RUNX1/AML1 as a classical tumor suppressor gene
    Silva, FPG
    Morolli, B
    Storlazzi, CT
    Anelli, L
    Wessels, H
    Bezrookove, V
    Kluin-Nelemans, HC
    Giphart-Gassler, M
    ONCOGENE, 2003, 22 (04) : 538 - 547
  • [5] Identification of RUNX1/AML1 as a classical tumor suppressor gene
    Fernando P G Silva
    Bruno Morolli
    Clelia T Storlazzi
    Luisa Anelli
    Hans Wessels
    Vladimir Bezrookove
    Hanneke C Kluin-Nelemans
    Micheline Giphart-Gassler
    Oncogene, 2003, 22 : 538 - 547
  • [6] Runx1/AML1 in Normal and Abnormal Hematopoiesis
    Tetsuya Yamagata
    Kazuhiro Maki
    Kinuko Mitani
    International Journal of Hematology, 2005, 82 : 1 - 8
  • [7] RUNX1/AML1: A Central Player in Hematopoiesis
    Tsukasa Okuda
    Motohiro Nishimura
    Mitsushige Nakao
    Yasuko Fujitaa
    International Journal of Hematology, 2001, 74 : 252 - 257
  • [8] RUNX1/AML1: A central player in hematopoiesis
    Okuda, T
    Nishimura, M
    Nakao, M
    Fujita, Y
    INTERNATIONAL JOURNAL OF HEMATOLOGY, 2001, 74 (03) : 252 - 257
  • [9] Runx1/AML1 in leukemia: disrupted association with diverse protein partners
    Perry, C
    Eldor, A
    Soreq, H
    LEUKEMIA RESEARCH, 2002, 26 (03) : 221 - 228
  • [10] Point mutations in the AML1/RUNX1 gene associated with myelodysplastic syndrome
    Harada, H
    Harada, Y
    CRITICAL REVIEWS IN EUKARYOTIC GENE EXPRESSION, 2005, 15 (03): : 183 - 196
12345