The Multifaceted Roles of MSCs in the Tumor Microenvironment: Interactions With Immune Cells and Exploitation for Therapy

被引：34

作者：

Papait, Andrea ^{[1
]}

Stefani, Francesca Romana ^{[1
]}

Cargnoni, Anna ^{[1
]}

Magatti, Marta ^{[1
]}

Parolini, Ornella ^{[2
,3
]}

Silini, Antonietta Rosa ^{[1
]}

机构：

[1] Fdn Poliambulanza Ist Osped, Ctr Ric E Menni, Brescia, Italy

[2] Univ Cattolica Sacro Cuore, Dept Life Sci & Publ Hlth, Rome, Italy

[3] Fdn Policlin Univ Agostino Gemelli IRCCS, Rome, Italy

来源：

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY | 2020年 / 8卷

关键词：

perinatal; placenta; mesenchymal stromal cells; cancer; tumor microenvironment; inflammation; immunosurveillance; immunoediting; MESENCHYMAL STEM-CELLS; MARROW-DERIVED MYOFIBROBLASTS; BREAST-CANCER CELLS; STROMAL CELLS; BONE-MARROW; IN-VITRO; AMNIOTIC MEMBRANE; NATURAL-KILLER; T-CELLS; FIBROBLASTS;

D O I：

10.3389/fcell.2020.00447

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The tumor microenvironment (TME) plays a critical role in tumorigenesis and is composed of different cellular components, including immune cells and mesenchymal stromal cells (MSCs). In this review, we will discuss MSCs in the TME setting and more specifically their interactions with immune cells and how they can both inhibit (immunosurveillance) and favor (immunoediting) tumor growth. We will also discuss how MSCs are used as a therapeutic strategy in cancer. Due to their unique immunomodulatory properties, MSCs isolated from perinatal tissues are intensely explored as therapeutic interventions in various inflammatory-based disorders with promising results. However, their therapeutic applications in cancer remain for the most part controversial and, importantly, the interactions between administered perinatal MSC and immune cells in the TME remain to be clearly defined.

引用

页数：13

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