Optimization of quantitative real-time polymerase chain reaction (qPCR)-based assessment of vector copy number as safety release criterion for clinical grade CAR T cell products

被引：0
|
作者：
Kunz, A. [1 ]
Gern, U. [1 ]
Schmitt, A. [1 ]
Neuber, B. [1 ]
Wang, L. [1 ]
Hueckelhoven-Krauss, A. [1 ]
Michels, B. [1 ]
Sellner, L. [1 ]
Hofmann, S. [1 ]
Mueller-Tidow, C. [1 ]
Dreger, P. [1 ]
Schmitt, M. [1 ]
Schubert, M. -L. [1 ]
机构：
[1] Univ Klinikum Heidelberg, Med Klin 5, Heidelberg, Germany
来源：
ONCOLOGY RESEARCH AND TREATMENT | 2019年 / 42卷
关键词：
D O I：
暂无
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
V845
引用
收藏
页码：238 / 239
页数：2
相关论文
共 39 条
  • [1] Optimization of quantitative real-time polymerase chain reaction (QPCR)-based assessment of vector copy number as safety release criterion for clinical grade CAR T cell therapy
    Kunz, Alexander
    Schubert, Maria-Luisa
    Gern, Ulrike
    Sellner, Leopold
    Schmitt, Anita
    Neuber, Brigitte
    Wang, Lei
    Hueckelhoven-Krauss, Angela
    Michels, Birgit
    Hofmann, Susanne
    Mueller-Tidow, Carsten
    Dreger, Peter
    Schmitt, Michael
    BONE MARROW TRANSPLANTATION, 2019, 54 : 519 - 520
  • [2] Quantitative real-time polymerase chain reaction for determination of plasmid copy number in bacteria
    Lee, Chal Lian
    Ow, Dave Siak Wei
    Oh, Steve Kah Weng
    JOURNAL OF MICROBIOLOGICAL METHODS, 2006, 65 (02) : 258 - 267
  • [3] The Potential Role of Plastome Copy Number as a Quality Biomarker for Plant Products using Real-time Quantitative Polymerase Chain Reaction
    Pandey, Amita
    Chaudhary, Shifa
    Bhat, Binu
    CURRENT GENOMICS, 2022, 23 (04) : 289 - 298
  • [4] NeoR-based transduced T lymphocytes detected by real-time quantitative polymerase chain reaction
    Venditti, G
    Di Ianni, M
    Falzetti, F
    Moretti, L
    Di Florio, S
    Tabilio, A
    JOURNAL OF HEMATOTHERAPY & STEM CELL RESEARCH, 2003, 12 (01): : 83 - 91
  • [5] Considerations in the development and validation of real-time quantitative polymerase chain reaction and its application in regulated bioanalysis to characterize the cellular kinetics of CAR-T products in clinical studies
    Yang, Tong-yuan
    Doddareddy, Rajitha
    BIOANALYSIS, 2021, 13 (02) : 115 - 128
  • [6] Quantitative determination of tumor cell intravasation in a real-time polymerase chain reaction-based assay
    Emilia Mira
    Rosa Ana Lacalle
    Concepción Gómez-Moutón
    Esther Leonardo
    Santos Mañes
    Clinical & Experimental Metastasis, 2002, 19 : 313 - 318
  • [7] Quantitative determination of tumor cell intravasation in a real-time polymerase chain reaction-based assay
    Mira, E
    Lacalle, RA
    Gómez-Moutón, C
    Leonardo, E
    Mañes, S
    CLINICAL & EXPERIMENTAL METASTASIS, 2002, 19 (04) : 313 - 318
  • [8] Digital polymerase chain reaction strategies for accurate and precise detection of vector copy number in chimeric antigen receptor T-cell products
    Murphy, Lindsey A.
    Marians, Russell C.
    Miller, Kristen
    Brenton, Matthew D.
    Mallo, Rebecca L. V.
    Kohler, M. Eric
    Fry, Terry J.
    Winters, Amanda C.
    CYTOTHERAPY, 2023, 25 (01) : 94 - 102
  • [9] Quantitative analysis of waterfowl parvoviruses in geese and Muscovy ducks by real-time polymerase chain reaction: correlation between age, clinical symptoms and DNA copy number of waterfowl parvoviruses
    Grzegorz Woźniakowski
    Elżbieta Samorek-Salamonowicz
    Wojciech Kozdruń
    BMC Veterinary Research, 8
  • [10] Quantitative analysis of waterfowl parvoviruses in geese and Muscovy ducks by real-time polymerase chain reaction: correlation between age, clinical symptoms and DNA copy number of waterfowl parvoviruses
    Wozniakowski, Grzegorz
    Samorek-Salamonowicz, Elzbieta
    Kozdrun, Wojciech
    BMC VETERINARY RESEARCH, 2012, 8
1234