Adverse drug events and the associated factors in patients with chronic Chagas disease

被引：1

作者：

da Cunha Lopes, Luiza Braz ^{[1
]}

Pereira, Raquel Rodrigues ^{[1
]}

Andrade, Patricia Mello ^{[1
]}

Carneiro, Fernanda Martins ^{[1
]}

Felix Mediano, Mauro Felippe ^{[1
]}

Linnemann Kilgore, Sophia Isabel ^{[1
]}

Hasslocher-Moreno, Alejandro Marcel ^{[1
]}

de Sousa, Andrea Silvestre ^{[1
]}

Evangelista Oliveira, Manoel Marques ^{[2
]}

Saraiva, Roberto Magalhaes ^{[1
]}

de Holanda, Marcelo Teixeira ^{[1
]}

Sperandio da Silva, Gilberto Marcelo ^{[1
]}

机构：

[1] Fundacao Oswaldo Cruz, Inst Nacl Infectol Evandro Chagas, Rio De Janeiro, RJ, Brazil

[2] Fundacao Oswaldo Cruz, Inst Oswaldo Cruz, Rio De Janeiro, RJ, Brazil

来源：

REVISTA DA SOCIEDADE BRASILEIRA DE MEDICINA TROPICAL | 2020年 / 53卷

关键词：

Chagas disease; Adverse drug event; Cardiomyopathy; SAFETY;

D O I：

10.1590/0037-8682-0443-2019

中图分类号：

R38 [医学寄生虫学]; Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ; 100103 ;

摘要：

Introduction: Herein, we aimed to identify the factors associated with adverse drug events (ADEs) in chronic Chagas disease (CD) patients. Methods: We analyzed 320 medical notes from 295 patients. The Naranjo algorithm was applied to determine the cause of ADEs. Mixed effects logistic regression was performed to evaluate the factors associated with ADEs. Results: ADEs were described in 102 medical notes (31.9%). Captopril was most frequently associated with ADEs. Age (RR 0.96; 95%CI 0.94-0.99) and cardiac C/D stages (RR 3.24; 95%CI 1.30-4.58) were the most important clinical factors associated with ADEs. Conclusions: Close follow-up is warranted for CD patients.

引用

页数：5

共 15 条

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