Synthesis and Antibacterial Activity of Quaternary Ammonium Salt-Type Antibacterial Agents with a Phosphate Group

被引：29

作者：

Ohta, Yumi ^{[1
]}

Kondo, Yukishige ^{[1
,2
]}

Kawada, Kazuo ^{[3
]}

Teranaka, Toshio ^{[4
]}

Yoshino, Norio ^{[1
,2
]}

机构：

[1] Tokyo Univ Sci, Dept Ind Chem, Fac Engn, Shinjuku Ku, Tokyo 1620826, Japan

[2] Tokyo Univ Sci, Res Inst Sci & Technol, Div Colloid & Interface Sci, Shinjuku Ku, Tokyo 1628601, Japan

[3] Kitasato Univ, Sch Sci, Dept Chem, Kanagawa 2288555, Japan

[4] Kanagawa Dent Coll, Div Restorat Dent, Dept Oral Med, Yokosuka, Kanagawa 2388580, Japan

来源：

JOURNAL OF OLEO SCIENCE | 2008年 / 57卷 / 08期

关键词：

antibacterial agent; synthesis; quaternary ammonium salt; phosphate group; minimum inhibitory concentration;

D O I：

10.5650/jos.57.445

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Quaternary ammonium salts are frequently used as antibacterial agent that disrupts cell membrane through the binding of their ammonium cations to anionic sites in the outer layer tissue of bacteria. This article describes the synthesis of quaternary ammonium salt-type antibacterial agents with a phosphate group that strongly binds to hydroxyapatite and bromide ion as counterion. Evaluation of the antibacterial activity of the synthesized compounds in terms of minimum inhibitory concentration (MIC test) showed that the compounds exhibit an excellent antibacterial activity on a variety of bacteria including Gram-positive and Gram-negative bacteria, yeast, and fungi.

引用

页码：445 / 452

页数：8

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