Graphene oxide-reinforced biodegradable genipin-cross-linked chitosan fluorescent biocomposite film and its cytocompatibility

被引：61
作者：
Li, Jianhua [1 ]
Ren, Na [1 ]
Qiu, Jichuan [1 ]
Mou, Xiaoning [2 ]
Liu, Hong [1 ,2 ]
机构：
[1] Shandong Univ, State Key Lab Crystal Mat, Ctr Bio & Micro Nano Funct Mat, Jinan 250100, Peoples R China
[2] Chinese Acad Sci, Beijing Inst Nanoenergy & Nanosyst, Beijing, Peoples R China
来源：
INTERNATIONAL JOURNAL OF NANOMEDICINE | 2013年 / 8卷
关键词：
chitosan film degradation; fluorescence; cytocompatibility; BIOCOMPATIBILITY; COMPOSITE; BIOMATERIALS; FABRICATION; STRENGTH; DELIVERY; PLATFORM; RELEASE; LINKING; CHITIN;
D O I：
10.2147/IJN.S51203
中图分类号：
TB3 [工程材料学];
学科分类号：
0805 ; 080502 ;
摘要：
A genipin-cross-linked chitosan/graphene oxide (GCS/GO) composite film was prepared using a solution casting method. Fourier transform infrared (FTIR) and ultraviolet-visible (UV-Vis) spectroscopy of the composite films showed that the interactions between the CS and oxygen-containing groups of GO resulted in good dispersion of the GO sheets in the CS network. The addition of GO decreased the expansion ratio of the composite films in physiological conditions and increased the resistance to degradation by lysozymes in vitro. As well, the tensile strength values of the GCS/GO films were significantly increased with the increasing load of GO. Moreover, the GCS/GO composite film also maintained the intrinsic fluorescence of GCS. The in vitro cell study results revealed that the composite films were suitable for the proliferation and adhesion of mouse preosteoblast (MC3T3-E1) cells. The GCS/GO biocomposite films might have a potential use in tissue engineering, bioimaging, and drug delivery.
引用
收藏
页码：3415 / 3426
页数：12
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