The potential involvement of P2X7 receptor in COVID-19 pathogenesis: A new therapeutic target?

被引：31
作者：
Pacheco, Paulo A. F. [1 ]
Faria, Robson X. [1 ]
机构：
[1] Fundacao Oswaldo Cruz, Inst Oswaldo Cruz, Lab Toxoplasmose & Outras Protozooses, Rio De Janeiro, Brazil
来源：
SCANDINAVIAN JOURNAL OF IMMUNOLOGY | 2021年 / 93卷 / 02期
关键词：
COVID-19; immunopathogenesis; NLRP3; inflammasome; SARS-CoV-2; RESPIRATORY-DISTRESS-SYNDROME; INDUCED LUNG INJURY; NLRP3; INFLAMMASOME; P2X(7) RECEPTOR; EXTRACELLULAR ATP; TH17; CELLS; INFECTION; PROTEIN; NEUTROPHILS; ACTIVATION;
D O I：
10.1111/sji.12960
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Coronavirus disease 2019 (COVID-19) pathogenesis remains under investigation. Growing evidence indicates the establishment of a hyperinflammatory response, characterized by sustained production of cytokines, such as IL-1 beta. The release and maturation of this cytokine are dependent on the activation of a catalytic multiprotein complex, known as "inflammasome". The most investigated is the NLRP3 inflammasome, which can be activated by various stimuli, such as the recognition of extracellular ATP by the P2X7 receptor. Based on the recent literature, we present evidence that supports the idea that the P2X7R/NLRP3 axis may be involved in the immune dysregulation caused by the SARS-CoV-2 infection.
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页数：9
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