PURPOSE: We reviewed the surgical results of vitrectomy for macular holes WHO associated with myopic foveoschisis (M-F). DESIGN: Noncomparative, interventional case series. METHODS: SETTING: Institutional. PARTICIPANTS: Eight eyes of eight patients with MHs associated with MF. INTERVENTION PROCEDURE: All patients underwent vitrectomy, internal limiting membrane peeling, and gas tamponade. MAIN OUTCOME MEASURES: Slit-lamp-based biomicroscopy, optical coherence tomography examinations, and best,corrected visual acuity (BCVA) measurement. RESULTS: The MHs closed in two eyes (25%), and the BCVA improved more than 2 lines in three (37.5%) eyes, remained unchanged in three (37.5%), and worsened in two (25%). The MH size increased significantly in a case with an unresolved MH (P <.05). The postoperative BCVA was significantly correlated with the preoperative BCVA (P <.05). CONCLUSIONS: Although significant visual improvement occurs in less than 50% of cases, vitrectomy can be beneficial for some cases.