New Alkaloids and Cytotoxic Principles from Sinomenium acutum

被引：35

作者：

Cheng, Jing-Jy ^{[1
,4
]}

Tsai, Tung-Hu ^{[2
]}

Lin, Lie-Chwen ^{[1
,3
]}

机构：

[1] Natl Res Inst Chinese Med, Taipei 112, Taiwan

[2] Natl Yang Ming Univ, Inst Tradit Med, Taipei 112, Taiwan

[3] China Med Univ, Grad Inst Integrated Med, Taichung, Taiwan

[4] Natl Yang Ming Univ, Inst Biophoton, Taipei 112, Taiwan

来源：

PLANTA MEDICA | 2012年 / 78卷 / 17期

关键词：

Sinomenium acutum; Menispermaceae; 2-demethyl-oxypalmatine; 5-ethoxycarbonylsinoracutine; cytotoxicity; angiogenesis; MENISPERMUM-DAURICUM DC; MORPHINANE ALKALOIDS; ACID-AMIDES; IN-VITRO; CONSTITUENTS; CORTEX; PLANTS; STEMS;

D O I：

10.1055/s-0032-1327785

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Two new alkaloids, 2-demethyl-oxypalmatine (1) and 5-ethoxycarbonylsinoracutine (2), were isolated from the rhizomes of Sinomenium acutum, along with thirty-four known compounds. Cytotoxicity of the isolated compounds was examined for the MCF-7, H460, HT-29, and CEM human cancer cell lines. Dauriporphine (16), 6-O-demethylmenisporphine (17), bianfugecine (18), menisporphine (19), and 6-O-demethyldauriporphine (20) showed differential effects in their cytotoxic activity on the target cancer cell lines. Significant angiogenesis inhibitions of 16 and 19 were also observed.

引用

页码：1873 / 1877

页数：5

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