Assessing DcR3 expression in relation to survivin and other prognostic factors in B cell non-Hodgkin's lymphoma

被引:13
作者
Bedewy, Ahmed M. L. [1 ]
Elgammal, Maha M. Adel [1 ]
Bedewy, Magdy M. L. [2 ]
EL-Maghraby, Shereen M. [1 ]
机构
[1] Univ Alexandria, Med Res Inst, Dept Hematol, Alexandria, Egypt
[2] Mil Med Acad, Dept Pathol, Cairo, Egypt
关键词
Non-Hodgkin's lymphoma; DLBCL; DcR3; Survivin; Immunohistochemistry; DECOY RECEPTOR-3; BONE-MARROW; MONOCLONAL-ANTIBODY; RESPONSE CRITERIA; FAS LIGAND; APOPTOSIS; AMPLIFICATION; CANCER; INVOLVEMENT; SUBTYPE;
D O I
10.1007/s00277-013-1775-4
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
The soluble decoy receptor 3 (DcR3) is a member of the tumor necrosis factor receptor superfamily whose overexpression has been observed in several human malignancies. Survivin is one of the inhibitors of apoptosis proteins that are thought to play an important role in the pathogenesis of malignancies. We aimed to evaluate the expression of DcR3 in relation to survivin in B cell non-Hodgkin's lymphoma (NHL) and then we focused on patients with diffuse large B cell non-Hodgkin's lymphoma (DLBCL) (50 cases) and correlated DcR3 expression with survivin expression and other prognostic parameters. Fifteen subjects with reactive lymphoid hyperplasia were included as controls. The expression of DcR3 and survivin were analyzed by immunohistochemistry on formalin-fixed paraffin-embedded lymph node sections from 80 cases of B cell NHL and 15 controls. Bone marrow biopsy sections of patients were also immunostained with the previous markers. Results: DcR3 expression was found in 32.5 % of B cell NHL patients versus 6.7 % of controls (p < 0.001) and was associated with the aggressive/highly aggressive subtypes. DcR3 was strongly expressed in 30 % of DLBCL patients, where it was associated with survivin expression, high international prognostic index (IPI), the presence of extra nodal disease, ECOG performance status >1, reduced remission rates and shorter event-free survival. The expression of survivin was 40 % in B cell NHL patients versus 13.3 % in the control group (p < 0.001). The expression of survivin in aggressive/highly aggressive B cell NHL was significantly higher than that in indolent B cell NHL. Survivin expression has been detected in 44 % of the DLBCL patients and was associated with their clinical stage and shorter event-free survival (p=0.026). Bone marrow biopsy sections from DLBCL patients showed significant DcR3 and survivin over expressions in sections with infiltration by lymphoma cells than sections with no infiltration. Conclusion: DcR3 expression was associated with other prognostic factors including survivin, reduced remission rates, and shorter event-free survival. Survivin is closely related to aggressive/highly aggressive subtypes of B cell NHL and is associated with shorter event-free survival. Both DcR3 and survivin expressions on bone marrow sections can be of help in diagnosing bone marrow infiltration.
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页码:1359 / 1367
页数:9
相关论文
共 46 条
  • [1] Adida C, 2000, BLOOD, V96, P1921
  • [2] Prognostic Significance of Cell Proliferation and Apoptosis-Regulating Proteins in Epstein-Barr Virus Positive and Negative Pediatric Non-Hodgkin's Lymphoma
    Aktas, Safiye
    Kargi, Aydanur
    Olgun, Nur
    Diniz, Gulden
    Erbay, Ayse
    Vergin, Canan
    [J]. PATHOLOGY & ONCOLOGY RESEARCH, 2009, 15 (03) : 345 - 350
  • [3] A novel anti-apoptosis gene, survivin, expressed in cancer and lymphoma
    Ambrosini, G
    Adida, C
    Altieri, DC
    [J]. NATURE MEDICINE, 1997, 3 (08) : 917 - 921
  • [4] [Anonymous], 2010, BASIC APPL PATHOL, DOI DOI 10.1111/J.1755-9294.2009.01063.X
  • [5] [Anonymous], NONHODGKIN LYMPHOMA
  • [6] [Anonymous], LEUK RES
  • [7] Bone marrow biopsy involvement by non-Hodgkin's lymphoma - Frequency of lymphoma types, patterns, blood involvement, and discordance with other sites in 450 specimens
    Arber, DA
    George, TI
    [J]. AMERICAN JOURNAL OF SURGICAL PATHOLOGY, 2005, 29 (12) : 1549 - 1557
  • [8] Overexpression of M68/DcR3 in human gastrointestinal tract tumors independent of gene amplification and its location in a four-gene cluster
    Bai, C
    Connolly, B
    Metzker, ML
    Hilliard, CA
    Liu, XM
    Sandig, V
    Soderman, A
    Galloway, SM
    Liu, QY
    Austin, CP
    Caskey, CT
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2000, 97 (03) : 1230 - 1235
  • [9] LYMPHOPROLIFERATIONS IN THE BONE-MARROW - IDENTIFICATION AND EVOLUTION - CLASSIFICATION AND STAGING
    BARTL, R
    FRISCH, B
    BURKHARDT, R
    JAGER, K
    PAPPENBERGER, R
    HOFFMANNFEZER, G
    [J]. JOURNAL OF CLINICAL PATHOLOGY, 1984, 37 (03) : 233 - 254
  • [10] The prognostic impact of bone marrow involvement in patients with diffuse large cell lymphoma varies according to the degree of infiltration and presence of discordant marrow involvement
    Campbell, J
    Seymour, JF
    Matthews, J
    Wolf, M
    Stone, J
    Juneja, S
    [J]. EUROPEAN JOURNAL OF HAEMATOLOGY, 2006, 76 (06) : 473 - 480