Biochemistry of adipose tissue: an endocrine organ

被引：803

作者：

Coelho, Marisa ^{[1
,2
,3
]}

Oliveira, Teresa ^{[3
]}

Fernandes, Ruben ^{[1
,2
,3
]}

机构：

[1] Inst Politecn Porto, Escola Super Tecnol Saude Porto, Ctr Invest Saude & Ambiente, Oporto, Portugal

[2] Inst Politecn Porto, Escola Super Tecnol Saude Porto, Ctr Invest Saude & Ambiente, Unidade Mecanismos Mol Doenca, Oporto, Portugal

[3] Univ Porto, Fac Med, Ctr Farmacol & Biopatol Quim FCT U38, Oporto, Portugal

来源：

ARCHIVES OF MEDICAL SCIENCE | 2013年 / 9卷 / 02期

关键词：

adipose tissue; adipocytes; adipokines; ACYLATION-STIMULATING PROTEIN; INSULIN SENSITIVITY; METABOLIC SYNDROME; ANGIOTENSIN-II; GLUCOSE-UPTAKE; ADIPONECTIN; VISFATIN; RESISTIN; OBESITY; ADIPOCYTOKINES;

D O I：

10.5114/aoms.2013.33181

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Adipose tissue is no longer considered to be an inert tissue that stores fat. This tissue is capable of expanding to accommodate increased lipids through hypertrophy of existing adipocytes and by initiating differentiation of pre-adipocytes. Adipose tissue metabolism exerts an impact on whole-body metabolism. As an endocrine organ, adipose tissue is responsible for the synthesis and secretion of several hormones. These are active in a range of processes, such as control of nutritional intake (leptin, angiotensin), control of sensitivity to insulin and inflammatory process mediators (tumor necrosis factor alpha (TNF-alpha), interleukin-6 (IL-6), resistin, visfatin, adiponectin, among others) and pathways (plasminogen activator inhibitor 1 (PAI-1) and acylation stimulating protein (ASP) for example). This paper reviews some of the biochemical and metabolic aspects of adipose tissue and its relationship to inflammatory disease and insulin resistance.

引用

页码：191 / 200

页数：10

共 51 条

[1] Adipose tissue as an endocrine organ [J].

Ahima, RS ;

Flier, JS .

TRENDS IN ENDOCRINOLOGY AND METABOLISM, 2000, 11 (08) :327-332

[2]

Bernlohr D.A., 2002, NEW COMPREHENSIVE BI, V36, P263

[3] Local and systemic insulin resistance resulting from hepatic activation of IKK-β and NF-κB [J].

Cai, DS ;

Yuan, MS ;

Frantz, DF ;

Melendez, PA ;

Hansen, L ;

Lee, J ;

Shoelson, SE .

NATURE MEDICINE, 2005, 11 (02) :183-190

[4] Interleukin-6 increases insulin-stimulated glucose disposal in humans and glucose uptake and fatty acid oxidation in vitro via AMP-activated protein kinase [J].

Carey, Andrew L. ;

Steinberg, Gregory R. ;

Macaulay, S. Lance ;

Thomas, Walter G. ;

Holmes, Anna G. ;

Ramm, Georg ;

Prelovsek, Oja ;

Hohnen-Behrens, Cordula ;

Watt, Matthew J. ;

James, David E. ;

Kemp, Bruce E. ;

Pedersen, Bente K. ;

Febbraio, Mark A. .

DIABETES, 2006, 55 (10) :2688-2697

[5] Adiponectin, acylation stimulating protein and complement C3 are altered in obesity in very young children [J].

Cianflone, K ;

Lu, HL ;

Smith, J ;

Yu, W ;

Wang, HW .

CLINICAL ENDOCRINOLOGY, 2005, 62 (05) :567-572

[6] Critical review of acylation-stimulating protein physiology in humans and rodents [J].

Cianflone, K ;

Xia, ZN ;

Chen, LY .

BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES, 2003, 1609 (02) :127-143

[7] A role for plasminogen activator inhibitor-1 in obesity: From pie to PAI? [J].

Correia, Marcelo L. G. ;

Haynes, William G. .

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 2006, 26 (10) :2183-2185

[8]

Costa Joana V, 2006, Acta Med Port, V19, P251

[9]

Diamond F., 2002, GROWTH GENET HORM, V18, P17

[10]

Fonseca-Alaniz Miriam H., 2006, Arq Bras Endocrinol Metab, V50, P216, DOI 10.1590/S0004-27302006000200008

← 1 2 3 4 5 6 →