The structure of polyunsaturated lipid bilayers important for rhodopsin function: A neutron diffraction study

被引：26

作者：

Mihailescu, M

Gawrisch, K ^{[1
]}

机构：

[1] Univ Calif Irvine, Dept Physiol & Biophys, Irvine, CA 92697 USA

[2] NIAAA, Lab Membrane Biochem & Biophys, NIH, Bethesda, MD 20892 USA

来源：

BIOPHYSICAL JOURNAL | 2006年 / 90卷 / 01期

关键词：

D O I：

10.1529/biophysj.105.071712

中图分类号：

Q6 [生物物理学];

学科分类号：

071011 ;

摘要：

The structure of oriented 1-stearoyl-2-docosahexaenoyl-sn-glycero-3- phosphocholine bilayers with perdeuterated stearoyl-or docosahexaenoyl hydrocarbon chains was investigated by neutron diffraction. Experiments were conducted at two different relative humidities, 66 and 86%. At both humidities we observed that the polyunsaturated docosahexaenoyl chain has a preference to reside near the lipid water interface. That leaves voids in the bilayer center that are occupied by saturated stearoyl chain segments. This uneven distribution of saturated-and polyunsaturated chain densities is likely to result in membrane elastic stress that modulates function of integral receptor proteins like rhodopsin.

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页码：L4 / L6

页数：3

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