Antimicrobial Properties ofApis mellifera's Bee Venom

被引：74

作者：

El-Seedi, Hesham ^{[1
,2
,3
,4
]}

Abd El-Wahed, Aida ^{[4
,5
]}

Yosri, Nermeen ^{[4
,6
]}

Musharraf, Syed Ghulam ^{[7
]}

Chen, Lei ^{[8
]}

Moustafa, Moustafa ^{[9
]}

Zou, Xiaobo ^{[6
]}

Al-Mousawi, Saleh ^{[9
]}

Guo, Zhiming ^{[6
]}

Khatib, Alfi ^{[10
,11
]}

Khalifa, Shaden ^{[2
]}

机构：

[1] Jiangsu Univ, Int Res Ctr Food Nutr & Safety, Zhenjiang 212013, Jiangsu, Peoples R China

[2] Stockholm Univ, Wenner Gren Inst, Dept Mol Biosci, S-10691 Stockholm, Sweden

[3] Al Rayan Coll, Al Rayan Res & Innovat Ctr, Medina 42541, Saudi Arabia

[4] Menoufia Univ, Fac Sci, Dept Chem, Shibin Al Kawm 32512, Egypt

[5] Agr Res Ctr, Plant Protect Res Inst, Dept Bee Res, Giza 12627, Egypt

[6] Jiangsu Univ, Sch Food & Biol Engn, Zhenjiang 212013, Jiangsu, Peoples R China

[7] Univ Karachi, Int Ctr Chem & Biol Sci, HEJ Res Inst Chem, Karachi 75270, Pakistan

[8] Fujian Agr & Forestry Univ, Coll Food Sci, Fuzhou 350002, Peoples R China

[9] Univ Kuwait, Fac Sci, Dept Chem, Safat 13060, Kuwait

[10] Int Islamic Univ Malaysia, Fac Pharm, Dept Pharmaceut Chem, Kuantan 25200, Pahang, Malaysia

[11] Airlangga Univ, Fac Pharm, Surabaya 60155, Indonesia

来源：

TOXINS | 2020年 / 12卷 / 07期

基金：

瑞典研究理事会;

关键词：

bee venom; antimicrobial properties; melittin; apamin; phospholipase A2 (PLA2); APIS-MELLIFERA; HONEY-BEE; IN-VITRO; PHOSPHOLIPASE A(2); CECROPIN-A; ANTIFUNGAL ACTIVITY; CATIONIC PEPTIDES; ESCHERICHIA-COLI; MELITTIN; CELL;

D O I：

10.3390/toxins12070451

中图分类号：

TS2 [食品工业];

学科分类号：

0832 ;

摘要：

Bee venom (BV) is a rich source of secondary metabolites from honeybees (Apis melliferaL.). It contains a variety of bioactive ingredients including peptides, proteins, enzymes, and volatile metabolites. The compounds contribute to the venom's observed biological functions as per its anti-inflammatory and anticancer effects. The antimicrobial action of BV has been shown in vitro and in vivo experiments against bacteria, viruses, and fungi. The synergistic therapeutic interactions of BV with antibiotics has been reported. The synergistic effect contributes to a decrease in the loading and maintenance dosage, a decrease in the side effects of chemotherapy, and a decrease in drug resistance. To our knowledge, there have been no reviews on the impact of BV and its antimicrobial constituents thus far. The purpose of this review is to address the antimicrobial properties of BV and its compounds.

引用

页数：17

共 100 条

[1] Highly Synergistic Effects of Melittin with Conventional Antibiotics Against Multidrug-Resistant Isolates of Acinetobacter baumannii and Pseudomonas aeruginosa [J].