Mesoporous silica nanoparticles: synthesis methods and their therapeutic use-recent advances

被引:91
作者
Ghaferi, Mohsen [1 ]
Esfahani, Maedeh Koohi Moftakhari [2 ]
Raza, Aun [3 ]
Al Harthi, Sitah [3 ,4 ]
Shahmabadi, Hasan Ebrahimi [5 ]
Alavi, Seyed Ebrahim [3 ]
机构
[1] Islamic Azad Univ, Dept Chem Engn, Shahrood Branch, Shahrood, Iran
[2] Queensland Univ Technol, Mol Design & Synth Discipline, Sci & Engn Fac, Sch Chem Phys & Mech Engn, Brisbane, Qld, Australia
[3] Univ Queensland, Sch Pharm, 20 Cornwall St, Woolloongabba, Qld 4102, Australia
[4] Shaqra Univ, Coll Pharm, Dept Pharmaceut Sci, Dawadmi, Saudi Arabia
[5] Rafsanjan Univ Med Sci, Sch Med, Dept Microbiol, Rafsanjan 7717933777, Iran
关键词
Cancer; drug delivery; mesoporous silica nanoparticles; nanomaterial; nanotechnology; DRUG-DELIVERY SYSTEMS; IN-VIVO BIODISTRIBUTION; GRAPHENE QUANTUM DOTS; CONTROLLED-RELEASE; CO-DELIVERY; TARGETED DELIVERY; CANCER-THERAPY; PARTICLE-SIZE; INTRACELLULAR DELIVERY; NANOCOMPOSITE SPHERES;
D O I
10.1080/1061186X.2020.1812614
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Mesoporous silica nanoparticles (MSNPs) are a particular example of innovative nanomaterials for the development of drug delivery systems. MSNPs have recently received more attention for biological and pharmaceutical applications due to their capability to deliver therapeutic agents. Due to their unique structure, they can function as an effective carrier for the delivery of therapeutic agents to mitigate diseases progress, reduce inflammatory responses and consequently improve cancer treatment. The potency of MSNPs for the diagnosis and management of various diseases has been studied. This literature review will take an in-depth look into the properties of various types of MSNPs (e.g. shape, particle and pore size, surface area, pore volume and surface functionalisation), and discuss their characteristics, in terms of cellular uptake, drug delivery and release. MSNPs will then be discussed in terms of their therapeutic applications (passive and active tumour targeting, theranostics, biosensing and immunostimulative), biocompatibility and safety issues. Also, emerging trends and expected future advancements of this carrier will be provided.
引用
收藏
页码:131 / 154
页数:24
相关论文
共 344 条
[1]   Asymmetric mesoporous silica nanoparticles as potent and safe immunoadjuvants provoke high immune responses [J].
Abbaraju, Prasanna Lakshmi ;
Jambhrunkar, Manasi ;
Yang, Yannan ;
Liu, Yang ;
Lu, Yao ;
Yu, Chengzhong .
CHEMICAL COMMUNICATIONS, 2018, 54 (16) :2020-2023
[2]  
Acosta CM, 2014, CRIT ULTRASOUND J S1, V6, pA13
[3]   Mesoporous silica nanoparticle-based cisplatin prodrug delivery and anticancer effect under reductive cellular environment [J].
Ahn, Byungjun ;
Park, Juhee ;
Singha, Kaushik ;
Park, Hansoo ;
Kim, Won Jong .
JOURNAL OF MATERIALS CHEMISTRY B, 2013, 1 (22) :2829-2836
[4]   Nasal delivery of donepezil HCl-loaded hydrogels for the treatment of Alzheimer's disease [J].
Al Harthi, Sitah ;
Alavi, Seyed Ebrahim ;
Radwan, Mahasen Ali ;
El Khatib, Mona Mohamed ;
AlSarra, Ibrahim Abdullah .
SCIENTIFIC REPORTS, 2019, 9 (1)
[5]   Effect of Mesoporous Silica Nanoparticles on The Physicochemical Properties of Pectin Packaging Material for Strawberry Wrapping [J].
Al-Asmar, Asmaa ;
Giosafatto, C. Valeria L. ;
Sabbah, Mohammed ;
Sanchez, Alfredo ;
Villalonga Santana, Reynaldo ;
Mariniello, Loredana .
NANOMATERIALS, 2020, 10 (01)
[6]   Optimized Methods for the Production and Bioconjugation of Sit-eSpecific, Alkyne-Modified Glucagon-like Peptide-1 (GLP-1) Analogs to Azide-Modified Delivery Platforms Using Copper-Catalyzed Alkyne-Azide Cycloaddition [J].
Alavi, Seyed Ebrahim ;
Cabot, Peter John ;
Yap, Gee Yi ;
Moyle, Peter Michael .
BIOCONJUGATE CHEMISTRY, 2020, 31 (07) :1820-1834
[7]   Glucagon-Like Peptide-1 Receptor Agonists and Strategies To Improve Their Efficiency [J].
Alavi, Seyed Ebrahim ;
Cabot, Peter J. ;
Moyle, Peter M. .
MOLECULAR PHARMACEUTICS, 2019, 16 (06) :2278-2295
[8]   Cisplatin-Loaded Polybutylcyanoacrylate Nanoparticles with Improved Properties as an Anticancer Agent [J].
Alavi, Seyed Ebrahim ;
Al Harthi, Sitah Muflih ;
Shahmabadi, Hasan Ebrahimi ;
Akbarzadeh, Azim .
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2019, 20 (07)
[9]   In vitro evaluation of the efficacy of liposomal and pegylated liposomal hydroxyurea [J].
Alavi S.E. ;
Esfahani M.K.M. ;
Ghassemi S. ;
Akbarzadeh A. ;
Hassanshahi G. .
Indian Journal of Clinical Biochemistry, 2014, 29 (1) :84-88
[10]   Synthesis of lactoferrin mesoporous silica nanoparticles for pemetrexed/ellagic acid synergistic breast cancer therapy [J].
Ali, Omnia M. ;
Bekhit, Adnan A. ;
Khattab, Sherine N. ;
Helmy, Maged W. ;
Abdel-Ghany, Yasser S. ;
Teleb, Mohamed ;
Elzoghby, Ahmed O. .
COLLOIDS AND SURFACES B-BIOINTERFACES, 2020, 188