Retrospective Survey of Prodromal Symptoms in Dementia with Lewy Bodies: Comparison with Alzheimer's Disease

被引：63

作者：

Chiba, Yuhei ^{[2
,3
]}

Fujishiro, Hiroshige ^{[1
,2
]}

Iseki, Eizo ^{[2
]}

Ota, Kazumi

Kasanuki, Koji ^{[2
]}

Hirayasu, Yoshio ^{[3
]}

Sato, Kiyoshi

机构：

[1] Juntendo Univ, Sch Med, Juntendo Tokyo Koto Geriatr Med Ctr, PET CT Dementia Res Ctr,Koto Ku, Tokyo 1360075, Japan

[2] Juntendo Univ, Sch Med, Juntendo Tokyo Koto Geriatr Med Ctr, Dept Psychiat, Tokyo 1360075, Japan

[3] Yokohama City Univ, Sch Med, Dept Psychiat, Yokohama, Kanagawa 232, Japan

来源：

DEMENTIA AND GERIATRIC COGNITIVE DISORDERS | 2012年 / 33卷 / 04期

关键词：

Dementia with Lewy bodies; Alzheimer's disease; Rapid eye movement sleep behavior disorder; Olfactory dysfunction; Autonomic dysfunction; Early diagnosis; Brain positron emission tomography; Differential diagnosis; AUTOPSY-CONFIRMED DEMENTIA; SLEEP BEHAVIOR DISORDER; PARKINSON-DISEASE; BODY DISEASE; DIAGNOSIS; IMPAIRMENT; ASSOCIATION; DLB;

D O I：

10.1159/000339363

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

Background: Non-motor symptoms are recognized to enable the early detection of Parkinson's disease (PD). It remains unknown when those symptoms appear in dementia with Lewy bodies (DLB). Method: We investigated the prevalence of 15 non-motor symptoms of PD at the onset of memory loss based on a standardized worksheet in 34 patients with DLB, 32 patients with Alzheimer's disease (AD) and 30 normal controls. Results: DLB patients exhibited a significantly higher prevalence of olfactory dysfunction, constipation, increased saliva and signs of rapid eye movement sleep behavior disorder at the onset of memory loss than AD patients and normal controls. Conclusions: Paying attention to non-motor symptoms of PD may help DLB diagnosis in the early stage, especially in terms of its differentiation from AD. Copyright (C) 2012 S. Karger AG, Basel

引用

页码：273 / 281

页数：9

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