Polysaccharide extracted from Morchella esculenta inhibits carrageenan-induced thrombosis in mice

被引：16

作者：

Chen, Guilan ^{[1
]}

Liang, Yingquan ^{[1
]}

Wang, Dandan ^{[2
]}

Zhang, Feng ^{[1
]}

Huang, Rong ^{[1
]}

Ge, Yu ^{[1
]}

Liao, Chenzhong ^{[1
]}

Hao, Xuegong ^{[3
]}

Chen, Yuanli ^{[1
]}

Han, Jihong ^{[1
,4
]}

Yang, Xiaoxiao ^{[1
]}

Duan, Yajun ^{[1
]}

机构：

[1] Hefei Univ Technol, Anhui Higher Educ Inst, Sch Food & Biol Engn, Key Lab Metab & Regulat Major Dis, Hefei 230009, Peoples R China

[2] Anhui Univ Tradit Chinese Med, Sch Pharm, Hefei 230013, Peoples R China

[3] Anhui Miao Tang Pharmaceut Co Ltd, Fuyang 236400, Peoples R China

[4] Nankai Univ, Coll Life Sci, State Key Lab Med Chem Biol, Key Lab Bioact Mat,Minist Educ, Tianjin 300071, Peoples R China

来源：

JOURNAL OF FUNCTIONAL FOODS | 2022年 / 97卷

基金：

中国国家自然科学基金; 中国博士后科学基金;

关键词：

Morchella esculenta; Polysaccharide; Thrombosis; Platelets; HUVEC; PLATELET ACTIVATION; OXIDATIVE STRESS; IN-VIVO; HEMOSTASIS; MECHANISMS; THROMBOEMBOLISM; INFLAMMATION; ANTITUMOR; PATHWAY;

D O I：

10.1016/j.jff.2022.105235

中图分类号：

TS2 [食品工业];

学科分类号：

0832 ;

摘要：

Thrombosis is one of the leading causes of death worldwide and is associated with inflammation and oxidative stress. This study aims to investigate the effect of Morchella esculenta Polysaccharide (MCP) on thrombosis. Our results showed that MCP inhibited thrombi in blood vessels of mouse tail, liver and lung, which was contributed by the inhibition of collagen accumulation, tumor necrosis factor-alpha and P-selectin expression. In vitro, human platelet clot retraction test indicated that MCP inhibited platelet activation, which was related to inhibition of platelet receptors, AKT and ERK1/2 pathways. Additionally, MCP inhibited oxidative stress by inducing anti -oxidative enzymes in human platelets and human umbilical vein vascular endothelium cells (HUVECs). More-over, MCP inhibited oxidized low-density lipoprotein or LPS-induced adhesion of monocytes to HUVECs by reducing adhesion molecules expression. Taken together, these data demonstrate MCP exhibits antithrombotic properties, indicating Morchella esculenta can be used as food supplements and nutraceuticals against thrombosis.

引用

页数：11

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