Mechanisms of heme oxygenase-1 induction by cobalt protoporphyrin and cobalt chloride

被引：0
作者：
Loboda, Agnieszka [1 ]
Jozkowicz, Alicja [1 ]
Dulak, Jozef [1 ]
机构：
[1] Jagiellonian Univ, Fac Biochem Biophys & Biotechnol, Dept Med Biotechnol, Krakow, Poland
来源：
METAL IONS IN BIOLOGY AND MEDICINE, VOL 10 | 2008年 / 10卷
关键词：
HO-1; Nrf2; HIF-1; transcription factor;
D O I：
暂无
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Heme oxygenase-1 (HO-1) is claimed to have a protective effect in many diseases including cardiovascular disorders, renal failure or transplantation. Therefore, its induction can be considered as a therapeutic strategy. HO-1 expression is regulated mainly at the transcriptional level and many transcription factors and regulatory elements present in HO-1 gene were discovered. Among different HO-1 inducers, metals (like cobalt) and metalloporphyrins (e.g. cobalt protoporphyrin), which are used both in vitro and in vivo, act via discrete pathways. Here we describe the possible mechanisms involved in HO-1 regulation by those cobaltous compounds.
引用
收藏
页码：235 / 241
页数：7
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