μLED-based optical cochlear implants for spectrally selective activation of the auditory nerve

被引：37

作者：

Dieter, Alexander ^{[1
,2
,10
]}

Klein, Eric ^{[3
]}

Keppeler, Daniel ^{[1
]}

Jablonski, Lukasz ^{[1
,4
]}

Harczos, Tamas ^{[1
,4
]}

Hoch, Gerhard ^{[1
,4
]}

Rankovic, Vladan ^{[1
,4
,5
]}

Paul, Oliver ^{[3
,6
]}

Jeschke, Marcus ^{[1
,4
,7
]}

Ruther, Patrick ^{[3
,6
]}

Moser, Tobias ^{[1
,2
,4
,8
,9
]}

机构：

[1] Univ Med Ctr Gottingen, Inst Auditory Neurosci & InnerEarLab Univ, Gottingen, Germany

[2] Univ Gottingen, Gottingen Grad Sch Neurosci & Mol Biosci, Gottingen, Germany

[3] Univ Freiburg, Dept Microsyst Engn IMTEK, Freiburg, Germany

[4] German Primate Ctr, Auditory Neurosci & Optogenet Lab, Gottingen, Germany

[5] German Primate Ctr, Auditory Neurosci & Optogenet Lab, Restorat Cochlear Genom Grp, Gottingen, Germany

[6] Univ Freiburg, Cluster Excellence, Brainlinks BrainTools, Freiburg, Germany

[7] German Primate Ctr, Auditory Neurosci & Optogenet Lab, Cognit Hearing Primates Grp, Gottingen, Germany

[8] Max Planck Inst Expt Med, Auditory Neurosci Grp, Gottingen, Germany

[9] Univ Goettingen, Cluster Excellence Multiscale Bioimaging Mol Mach, Gottingen, Germany

[10] Univ Med Ctr Hamburg Eppendorf, Ctr Mol Neurobiol Hamburg, Synapt Wiring Lab, Hamburg, Germany

来源：

EMBO MOLECULAR MEDICINE | 2020年 / 12卷 / 08期

基金：

欧洲研究理事会;

关键词：

cochlear implant; hearing restoration; micro-LED; neural coding; optogenetics; INFRARED NEURAL STIMULATION; OPTOGENETIC STIMULATION; INFERIOR COLLICULUS; NEURONAL ACTIVATION; GERBIL; HEARING; RESPONSES; PATHWAY;

D O I：

10.15252/emmm.202012387

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Electrical cochlear implants (eCIs) partially restore hearing and enable speech comprehension to more than half a million users, thereby re-connecting deaf patients to the auditory scene surrounding them. Yet, eCIs suffer from limited spectral selectivity, resulting from current spread around each electrode contact and causing poor speech recognition in the presence of background noise. Optogenetic stimulation of the auditory nerve might overcome this limitation as light can be conveniently confined in space. Here, we combined virus-mediated optogenetic manipulation of cochlear spiral ganglion neurons (SGNs) and microsystems engineering to establish acute multi-channel optical cochlear implant (oCI) stimulation in adult Mongolian gerbils. oCIs based on 16 microscale thin-film light-emitting diodes (mu LEDs) evoked tonotopic activation of the auditory pathway with high spectral selectivity and modest power requirements in hearing and deaf gerbils. These results prove the feasibility of mu LED-based oCIs for spectrally selective activation of the auditory nerve.

引用

页数：12

共 41 条

[1] Phase contrast tomography of the mouse cochlea at microfocus x-ray sources [J].