Synthesis, Crystal Structure, and Biological Activity of an Mn(II) Complex Derived from 2,6-diacetylpyridine bis(N4-methylthiosemicarbazone)

被引：3

作者：

Lu, Y. ^{[1
]}

Li, J. ^{[2
]}

Li, M. ^{[1
]}

Chen, D. ^{[3
]}

机构：

[1] Henan Univ, Coll Chem & Chem Engn, Inst Mol & Crystal Engn, Henan Key Lab Polyoxometalate, Kaifeng, Peoples R China

[2] Henan Univ, Basic Expt Teaching Ctr, Kaifeng, Peoples R China

[3] Henan Univ, Coll Chem & Chem Engn, Inst Fine Chem & Engn, Kaifeng, Henan, Peoples R China

来源：

SYNTHESIS AND REACTIVITY IN INORGANIC METAL-ORGANIC AND NANO-METAL CHEMISTRY | 2014年 / 44卷 / 07期

基金：

中国国家自然科学基金;

关键词：

thiosemicarbazone; biological activity; manganese(II) complex; crystal structure; METAL-COMPLEXES; 2-BENZOYLPYRIDINE-DERIVED THIOSEMICARBAZONES; ANTIMICROBIAL ACTIVITIES; PLATINUM(II) COMPLEXES; NICKEL(II) COMPLEXES; 2-ACETYL PYRIDINE; IN-VITRO; SEMICARBAZONES;

D O I：

10.1080/15533174.2013.797454

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Transition metal complex [Mn(H2L)(H2O)(2)](CH3COO)(2) (1), where H2L = 2,6-diacetylpyridine bis(N (4)-methylthiosemicarba- zone), has been synthesized and characterized by elemental analysis, IR, mass spectrometry, and single-crystal X-ray diffraction. Complex 1 is depicted as a monomeric, seven-coordinated complex formed with one Mn(II) ion, one pentadentate N3S2 thiosemicarbazone ligand, and two oxygen atoms from two water molecules. Biological studies, carried out in vitro against K562 leukemia cells, have shown that the thiosemicarbazone moiety and its manganese(II) complex show distinctive differences in the biological property.

引用

页码：1068 / 1072

页数：5

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