A concise enantioselective synthesis of the guaiane sesquiterpene (-)- oxyphyllol

被引：8

作者：

Zahel, Martin ^{[1
]}

Metz, Peter ^{[1
]}

机构：

[1] Tech Univ Dresden, Fachrichtung Chem & Lebensmittelchem, D-01069 Dresden, Germany

来源：

BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY | 2013年 / 9卷

关键词：

asymmetric synthesis; hydration; natural products; terpenes; transannular epoxide opening; ALCOHOLS; DEOXYGENATION;

D O I：

10.3762/bjoc.9.239

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

(-)-Oxyphyllol was prepared in only 4 steps from an epoxy enone that already served as an intermediate for the total synthesis of the anticancer guaiane (-)-englerin A. A regio- and diastereoselective Co(II)-catalyzed hydration of the olefin and a transannular epoxide opening were used as the key reactions.

引用

页码：2028 / 2032

页数：5

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