Acrodermatitis Continua of Hallopeau Is a Clinical Phenotype of DITRA: Evidence that It Is a Variant of Pustular Psoriasis

被引：39

作者：

Abbas, Ossama ^{[1
]}

Itani, Salam ^{[1
]}

Ghosn, Samer ^{[1
]}

Kibbi, Abdul Ghani ^{[1
]}

Fidawi, Georges ^{[1
]}

Farooq, Muhammad ^{[3
]}

Shimomura, Yutaka ^{[3
]}

Kurban, Mazen ^{[1
,2
,4
]}

机构：

[1] Amer Univ Beirut, Med Ctr, Dept Dermatol, Beirut 11072020, Lebanon

[2] Amer Univ Beirut, Med Ctr, Dept Biochem & Mol Genet, Beirut 11072020, Lebanon

[3] Niigata Univ, Grad Sch Med & Dent Sci, Lab Genet Skin Dis, Niigata, Japan

[4] Columbia Univ, Dept Dermatol, Med Ctr, New York, NY 10027 USA

来源：

DERMATOLOGY | 2013年 / 226卷 / 01期

关键词：

Acrodermatitis continua of Hallopeau; Generalized pustular psoriasis; IL36RN gene; Mutations; ANTAGONIST ANAKINRA; MUTATIONS;

D O I：

10.1159/000346572

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Acrodermatitis continua of Hallopeau (ACH) is a rare, chronic, sterile, pustular eruption that predominantly affects the fingertips with nail involvement. While some consider ACH a distinct entity, many believe it to be a variant of pustular psoriasis, especially as cases of ACH progressing to generalized pustular psoriasis (GPP) have been reported. Recently, recessively inherited mutations in the IL36RN gene, which encodes interleukin-36 receptor antagonist (IL-36Ra), have been demonstrated to be the cause of familial GPP, a condition termed DITRA (deficiency of IL-36Ra). Here, we identified a homozygous missense mutation c.338C>T (p.Ser113Leu) in the IL36RN gene in a male patient with ACH, as well as in his sister who had a history of GPP. Copyright (C) 2013 S. Karger AG, Basel

引用

页码：28 / 31

页数：4

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