Post-Treatment Lyme Syndrome and Central Sensitization

被引：28

作者：

Batheja, Shweta

Nields, Jenifer A.

Landa, Alla

Fallon, Brian A. ^{[1
]}

机构：

[1] Columbia Univ, Dept Psychiat, New York, NY 10027 USA

来源：

JOURNAL OF NEUROPSYCHIATRY AND CLINICAL NEUROSCIENCES | 2013年 / 25卷 / 03期

关键词：

CHRONIC-FATIGUE-SYNDROME; CENTRAL SENSITIVITY SYNDROMES; IRRITABLE-BOWEL-SYNDROME; BORRELIA-BURGDORFERI; TEMPORAL SUMMATION; CHRONIC PAIN; ANTIBIOTIC-TREATMENT; 2ND PAIN; FIBROMYALGIA; DISEASE;

D O I：

10.1176/appi.neuropsych.12090223

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Central sensitization is a process that links a variety of chronic pain disorders that are characterized by hypersensitivity to noxious stimuli and pain in response to non-noxious stimuli. Among these disorders, treatments that act centrally may have greater efficacy than treatments acting peripherally. Because many individuals with post-treatment Lyme syndrome (PTLS) have a similar symptom cluster, central sensitization may be a process mediating or exacerbating their sensory processing. This article reviews central sensitization, reports new data on sensory hyperarousal in PTLS, explores the potential role of central sensitization in symptom chronicity, and suggests new directions for neurophysiologic and treatment research.

引用

页码：176 / 186

页数：11

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