A developmental switch of AMPA receptor subunits in neocortical pyramidal neurons

被引：269

作者：

Kumar, SS ^{[1
]}

Bacci, A ^{[1
]}

Kharazia, V ^{[1
]}

Huguenard, JR ^{[1
]}

机构：

[1] Stanford Univ, Med Ctr, Dept Neurol & Neurol Sci, Stanford, CA 94305 USA

来源：

JOURNAL OF NEUROSCIENCE | 2002年 / 22卷 / 08期

关键词：

AMPA receptors; GluR2; subunit; Ca2+ permeability; pyramidal neurons; neocortex; developmental switch;

D O I：

10.1523/JNEUROSCI.22-08-03005.2002

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

AMPA receptors mediate most of the fast excitatory neurotransmission in the brain, and those lacking the glutamate receptor 2 (GluR2) subunit are Ca2+-permeable and expressed in cortical structures primarily by inhibitory interneurons. Here we report that synaptic AMPA receptors of excitatory layer 5 pyramidal neurons in the rat neocortex are deficient in GluR2 in early development, approximately before postnatal day 16, as evidenced by their inwardly rectifying current-voltage relationship, blockade of AMPA receptor-mediated EPSCs by external and internal polyamines, permeability to Ca2+, and GluR2 immunoreactivity. Overall, these results indicate that neocortical pyramidal neurons undergo a developmental switch in the Ca2+ permeability of their AMPA receptors through an alteration of their subunit composition. This has important implications for plasticity and neurotoxicity.

引用

页码：3005 / 3015

页数：11

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