Gold(I)-catalyzed enantioselective bromocyclization reactions of allenes

被引：72

作者：

Miles, Dillon H. ^{[1
]}

Veguillas, Marcos ^{[1
]}

Toste, F. Dean ^{[1
]}

机构：

[1] Univ Calif Berkeley, Dept Chem, Berkeley, CA 94720 USA

来源：

CHEMICAL SCIENCE | 2013年 / 4卷 / 09期

关键词：

INTRAMOLECULAR HYDROAMINATION; ELECTROPHILIC FLUORINATION; EFFICIENT PREPARATION; ORGANOGOLD COMPOUNDS; FACILE SYNTHESIS; CHIRAL ANIONS; ACID; BROMOLACTONIZATION; REACTIVITY; COMPLEXES;

D O I：

10.1039/c3sc50811k

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The enantioselective bromocyclization of allenes is accomplished through the use of a chiral dinuclear gold complex and/or chiral phosphate anions in the presence of an N-bromolactam as an electrophilic bromine source. This method provides access to heterocyclic vinyl bromides with an allylic stereocenter in excellent yield and enantioselectivity. These enantioenriched vinyl bromides may serve as a handle for further derivatization via cross-coupling reactions.

引用

页码：3427 / 3431

页数：5

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