Direct sp3 C?H Amination of Nitrogen-Containing Benzoheterocycles Mediated by Visible-Light-Photoredox Catalysts

被引：99

作者：

Miyake, Yoshihiro ^{[1
]}

Nakajima, Kazunari ^{[1
]}

Nishibayashi, Yoshiaki ^{[1
]}

机构：

[1] Univ Tokyo, Sch Engn, Inst Engn Innovat, Bunkyo Ku, Tokyo 1138656, Japan

来源：

CHEMISTRY-A EUROPEAN JOURNAL | 2012年 / 18卷 / 51期

关键词：

amination; heterocycles; photocatalysts; redox chemistry; DEHYDROGENATIVE COUPLING REACTION; PHOTOINDUCED HYDROGEN-PRODUCTION; H BOND ADJACENT; TERTIARY-AMINES; ELECTRON-TRANSFER; ELECTROOXIDATIVE CYCLIZATION; DIETHYL AZODICARBOXYLATE; HYDROQUINOLYL ALCOHOLS; SYNTHETIC STRATEGY; RADICAL-ADDITION;

D O I：

10.1002/chem.201203066

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Visible-light-mediated direct sp3 C?H amination of benzocyclic amines via a-aminoalkyl radicals by using photoredox catalysts is described here. The obtained N,N-acetals were also successfully applied for carboncarbon bond forming reactions with carbon nucleophiles. The procedure is suitable for a late-stage modification of C?H bonds to C?C bonds.

引用

页码：16473 / 16477

页数：5

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