Neutrophil in viral infections, friend or foe?

被引:89
作者
Drescher, Brandon [1 ]
Bai, Fengwei [1 ]
机构
[1] Univ So Mississippi, Dept Biol Sci, Hattiesburg, MS 39406 USA
基金
美国国家卫生研究院;
关键词
Neutrophil; Viral pathogenesis; HUMAN POLYMORPHONUCLEAR LEUKOCYTES; COLONY-STIMULATING FACTOR; WEST-NILE ENCEPHALITIS; PROGRAMMED CELL-DEATH; INFLUENZA-A-VIRUS; EXTRACELLULAR TRAPS; CANDIDA-ALBICANS; ANTIMICROBIAL ACTIVITY; STAPHYLOCOCCUS-AUREUS; MITOCHONDRIAL-DNA;
D O I
10.1016/j.virusres.2012.11.002
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
Polymorphonuclear leukocytes or neutrophils are the first immune cells to the site of injury and microbial infection. Neutrophils are crucial players in controlling bacterial and fungal infections, and in particular secondary infections, by phagocytosis, degranulation and neutrophil extracellular traps (NETs). While neutrophils have been shown to play important roles in viral pathogenesis, there is a lack of detailed investigation. In this article, we will review recent progresses toward understanding the role of neutrophils in viral pathogenesis. (C) 2012 Elsevier B.V. All rights reserved.
引用
收藏
页码:1 / 7
页数:7
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