The Synthesis and Preliminary Activity Assay In Vitro of Andrographolide Derivatives

被引：0

作者：

Xu, WeiDong ^{[1
]}

Liu, Ya ^{[1
]}

Tu, GuoGang ^{[1
]}

Lai, XiaoPing ^{[1
]}

Kuang, BinHai ^{[1
]}

Li, ShaoHua ^{[1
]}

机构：

[1] NanChang Univ, Sch Pharmaceut Sci, Dept Med Chem, 461 BaYi Rd, Nanchang 330006, Jiangxi, Peoples R China

来源：

LATIN AMERICAN JOURNAL OF PHARMACY | 2016年 / 35卷 / 10期

基金：

中国国家自然科学基金;

关键词：

andrographolide; anticancer; synthesis; ANTICANCER ACTIVITY; CYTOTOXIC AGENTS; DISCOVERY; CELLS;

D O I：

暂无

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Andrographolide, the major labdane diterpenoid from Andrographis paniculata has been reported to be cytotoxic against various cancer cells in vitro. A series of novel andrographolide derivatives were designed and synthesized as antitumor agents. The structures were confirmed by IR, H-1-NMR, and MS. Comparing to andrographolide, most of target compounds showed moderate inhibition activity against human tongue cancer cell line. But all of them displayed low antiproliferative activities. However, 3, 19-cyclophosphate derivatives (7-9) showed relatively high antiproliferative activity, and could be used as lead compounds for exploring new type antitumor agents in the future.

引用

页码：2234 / 2239

页数：6

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