Sinonasal SMARCB1 (INI1) Deficient Carcinoma With Yolk Sac Tumor Differentiation: Report of a Case and Comparison With INI1 Expression in Gonadal Germ Cell Tumors

被引：27
作者：
Zamecnik, Michal [1 ,2 ]
Rychnovsky, Jiri [1 ]
Syrovatka, Jakub [3 ]
机构：
[1] Agel Labs As, Dept Pathol, Novy Jicin, Czech Republic
[2] Medirex Grp Acad, Bratislava, Slovakia
[3] Agel Hosp, Dept Otorhinolaryngol Head & Neck Surg, Novy Jicin, Czech Republic
来源：
INTERNATIONAL JOURNAL OF SURGICAL PATHOLOGY | 2018年 / 26卷 / 03期
关键词：
SMARCB1 (INI1) deficient carcinoma; sinonasal carcinoma; yolk sac tumor; gonadal mixed germ cell tumor; ENDODERMAL SINUS TUMOR; PARA-NASAL SINUSES; MALIGNANT TERATOMA; HYPERCALCEMIC TYPE; NEOPLASIA; FEATURES;
D O I：
10.1177/1066896917741549
中图分类号：
R36 [病理学];
学科分类号：
100104 ;
摘要：
SMARCB1 (INI1) deficient sinonasal carcinoma is a recently recognized entity with wide histomorphologic spectrum. We present a case of this carcinoma that contained, in addition to a common morphology, scattered foci of yolk sac tumor differentiation. The tumor occurred in paranasal sinuses in a 44-year-old woman. Immunohistochemically, it was diffusely negative for INI1, whereas an expression of yolk sac tumor markers (-fetoprotein, glypican-3, CDX2) was limited to the yolk sac tumor component. For comparison with the present case, we performed INI1 immunostaining on a series of 11 gonadal germ cell tumors with yolk sac tumor differentiation. All of these cases showed strong and diffuse expression of INI1, in contrast with the present sinonasal tumor. Our findings expand the morphologic spectrum of SMARCB1 (INI1) deficient sinonasal carcinoma. In addition, we show preliminarily that gonadal germ cell tumors with yolk sac tumor differentiation are not SMARCB1/INI1-deficient.
引用
收藏
页码：245 / 249
页数：5
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